4YCU

Crystal structure of cladosporin in complex with human lysyl-tRNA synthetase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Lysine--tRNA ligase	polymer	513	59240.1	2	UniProt (Q15046) Pfam (PF01336) Pfam (PF00152)	Homo sapiens (Human)	Lysyl-tRNA synthetase,LysRS
2	C (C)	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2	polymer	42	4911.7	1	UniProt (Q13155) Pfam (PF16780)	Homo sapiens (Human)	Multisynthase complex auxiliary component p38,Protein JTV-1
3	D, H (A, B)	cladosporin	non-polymer		292.3	2	Chemie (KRS)
4	E, I (A, B)	LYSINE	non-polymer		147.2	2	Chemie (LYS)
5	F, G, J, K (A, B)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
6	L, M, N (A, B, C)	water	water		18.0	696	Chemie (HOH)

Sequence modifications

A, B: 70 - 581 (UniProt: Q15046)

PDB	External Database	Details
Met 69	-	initiating methionine

C: 1 - 36 (UniProt: Q13155)

PDB	External Database	Details
His 37	-	expression tag
His 38	-	expression tag
His 39	-	expression tag
His 40	-	expression tag
His 41	-	expression tag
His 42	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	123391.9
Non-Polymers*	Number of molecules	8
	Total formula weight	1247.4
All*	Total formula weight	124639.4

*Water molecules are not included.