4YCA

Evidence of Kinetic Cooperativity in dimeric Ketopantoate Reductase from Staphylococcus aureus

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	2-dehydropantoate 2-reductase	polymer	294	33435.9	2	UniProt (W8TQG0) Pfam (PF02558) Pfam (PF08546) UniProt (by SIFTS) (A0A0J9X283)	Staphylococcus aureus
2	C, D (A, B)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
3	E, F (A, B)	water	water		18.0	411	Chemie (HOH)

Sequence modifications

A, B: 3 - 286 (UniProt: W8TQG0)

PDB	External Database	Details
Met 1	-	initiating methionine
Ser 2	-	expression tag
Glu 287	-	expression tag
Gly 288	-	expression tag
His 289	-	expression tag
His 290	-	expression tag
His 291	-	expression tag
His 292	-	expression tag
His 293	-	expression tag
His 294	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66871.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1490.8
All*	Total formula weight	68362.7

*Water molecules are not included.