4Y00
Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | TAR DNA-binding protein 43 | polymer | 103 | 12006.7 | 4 | UniProt (Q13148) Pfam (PF00076) In PDB | Homo sapiens (Human) | TDP-43 |
2 | E, F, G, H | DNA (5'-D(P*TP*TP*GP*AP*GP*CP*GP*T)-3') | polymer | 10 | 3091.0 | 4 | Homo sapiens | ||
3 | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 101 - 191 (UniProt: Q13148)
PDB | External Database | Details |
---|---|---|
Met 89 | - | expression tag |
Arg 90 | - | expression tag |
Gly 91 | - | expression tag |
Ser 92 | - | expression tag |
His 93 | - | expression tag |
His 94 | - | expression tag |
His 95 | - | expression tag |
His 96 | - | expression tag |
His 97 | - | expression tag |
His 98 | - | expression tag |
Gly 99 | - | expression tag |
Ser 100 | - | expression tag |
Gly 169 | Asp 169 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 60390.9 | |
All* | Total formula weight | 60390.9 |