4Y00

Crystal Structure of Human TDP-43 RRM1 Domain with D169G Mutation in Complex with an Unmodified Single-stranded DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	TAR DNA-binding protein 43	polymer	103	12006.7	4	UniProt (Q13148) Pfam (PF00076)	Homo sapiens (Human)	TDP-43
2	E, F, G, H (E, F, G, H)	DNA (5'-D(P*TP*TP*GP*AP*GP*CP*GP*T)-3')	polymer	10	3091.0	4		Homo sapiens
3	I, J, K, L, M... (A, B, C, D, E...)	water	water		18.0	24	Chemie (HOH)

Sequence modifications

A, B, C, D: 101 - 191 (UniProt: Q13148)

PDB	External Database	Details
Met 89	-	expression tag
Arg 90	-	expression tag
Gly 91	-	expression tag
Ser 92	-	expression tag
His 93	-	expression tag
His 94	-	expression tag
His 95	-	expression tag
His 96	-	expression tag
His 97	-	expression tag
His 98	-	expression tag
Gly 99	-	expression tag
Ser 100	-	expression tag
Gly 169	Asp 169	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	60390.9
All*	Total formula weight	60390.9

*Water molecules are not included.