4XZ2

Human platelet phosphofructokinase in an R-state in complex with ADP and F6P, crystal form I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	ATP-dependent 6-phosphofructokinase, platelet type	polymer	761	83161.0	4	UniProt (Q01813) Pfam (PF00365)	Homo sapiens (Human)	PFK-P,6-phosphofructokinase type C,Phosphofructo-1-kinase isozyme C,PFK-C,Phosphohexokinase
2	E, J, K, M, Q... (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	6	Chemie (PO4)
3	F, H, L, O (A, B, C, D)	1,6-di-O-phosphono-beta-D-fructofuranose	non-polymer		340.1	4	Chemie (FBP)
4	G, N (B, D)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
5	I, P (B, D)	6-O-phosphono-beta-D-fructofuranose	non-polymer		260.1	2	Chemie (F6P)

Sequence modifications

A, B, C, D: 26 - 762 (UniProt: Q01813)

PDB	External Database	Details
Met 2	-	initiating methionine
Ala 3	-	expression tag
Ser 4	-	expression tag
Trp 5	-	expression tag
Ser 6	-	expression tag
His 7	-	expression tag
Pro 8	-	expression tag
Gln 9	-	expression tag
Phe 10	-	expression tag
Glu 11	-	expression tag
Lys 12	-	expression tag
Gly 13	-	expression tag
Ala 14	-	expression tag
Asp 15	-	expression tag
Asp 16	-	expression tag
Asp 17	-	expression tag
Asp 18	-	expression tag
Lys 19	-	expression tag
Val 20	-	expression tag
Pro 21	-	expression tag
Asp 22	-	expression tag
Pro 23	-	expression tag
Thr 24	-	expression tag
Ser 25	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	332644.1
Non-Polymers*	Number of molecules	14
	Total formula weight	3305.0
All*	Total formula weight	335949.1

*Water molecules are not included.