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4XZ2

Human platelet phosphofructokinase in an R-state in complex with ADP and F6P, crystal form I

Functional Information from GO Data
ChainGOidnamespacecontents
A0003872molecular_function6-phosphofructokinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005945cellular_component6-phosphofructokinase complex
A0006002biological_processfructose 6-phosphate metabolic process
A0006096biological_processglycolytic process
A0016020cellular_componentmembrane
A0016208molecular_functionAMP binding
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0042802molecular_functionidentical protein binding
A0044877molecular_functionprotein-containing complex binding
A0045296molecular_functioncadherin binding
A0046872molecular_functionmetal ion binding
A0048029molecular_functionmonosaccharide binding
A0061621biological_processcanonical glycolysis
A0070062cellular_componentextracellular exosome
A0070095molecular_functionfructose-6-phosphate binding
A1990830biological_processcellular response to leukemia inhibitory factor
B0003872molecular_function6-phosphofructokinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005945cellular_component6-phosphofructokinase complex
B0006002biological_processfructose 6-phosphate metabolic process
B0006096biological_processglycolytic process
B0016020cellular_componentmembrane
B0016208molecular_functionAMP binding
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0042802molecular_functionidentical protein binding
B0044877molecular_functionprotein-containing complex binding
B0045296molecular_functioncadherin binding
B0046872molecular_functionmetal ion binding
B0048029molecular_functionmonosaccharide binding
B0061621biological_processcanonical glycolysis
B0070062cellular_componentextracellular exosome
B0070095molecular_functionfructose-6-phosphate binding
B1990830biological_processcellular response to leukemia inhibitory factor
C0003872molecular_function6-phosphofructokinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005945cellular_component6-phosphofructokinase complex
C0006002biological_processfructose 6-phosphate metabolic process
C0006096biological_processglycolytic process
C0016020cellular_componentmembrane
C0016208molecular_functionAMP binding
C0016301molecular_functionkinase activity
C0016310biological_processphosphorylation
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0042802molecular_functionidentical protein binding
C0044877molecular_functionprotein-containing complex binding
C0045296molecular_functioncadherin binding
C0046872molecular_functionmetal ion binding
C0048029molecular_functionmonosaccharide binding
C0061621biological_processcanonical glycolysis
C0070062cellular_componentextracellular exosome
C0070095molecular_functionfructose-6-phosphate binding
C1990830biological_processcellular response to leukemia inhibitory factor
D0003872molecular_function6-phosphofructokinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005945cellular_component6-phosphofructokinase complex
D0006002biological_processfructose 6-phosphate metabolic process
D0006096biological_processglycolytic process
D0016020cellular_componentmembrane
D0016208molecular_functionAMP binding
D0016301molecular_functionkinase activity
D0016310biological_processphosphorylation
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0042802molecular_functionidentical protein binding
D0044877molecular_functionprotein-containing complex binding
D0045296molecular_functioncadherin binding
D0046872molecular_functionmetal ion binding
D0048029molecular_functionmonosaccharide binding
D0061621biological_processcanonical glycolysis
D0070062cellular_componentextracellular exosome
D0070095molecular_functionfructose-6-phosphate binding
D1990830biological_processcellular response to leukemia inhibitory factor
Functional Information from PROSITE/UniProt
site_idPS00433
Number of Residues19
DetailsPHOSPHOFRUCTOKINASE Phosphofructokinase signature. RvtilGHvQRGGtpsafDR
ChainResidueDetails
AARG301-ARG319
AARG665-ARG683

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03184
ChainResidueDetails
AASP175
BASP175
CASP175
DASP175

site_idSWS_FT_FI2
Number of Residues32
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03184
ChainResidueDetails
AGLY34
BARG97
BGLY127
BASP128
BARG210
BARG301
BARG576
BARG665
CGLY34
CARG97
CGLY127
AARG97
CASP128
CARG210
CARG301
CARG576
CARG665
DGLY34
DARG97
DGLY127
DASP128
DARG210
AGLY127
DARG301
DARG576
DARG665
AASP128
AARG210
AARG301
AARG576
AARG665
BGLY34

site_idSWS_FT_FI3
Number of Residues40
DetailsBINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03184
ChainResidueDetails
ASER173
AARG744
BSER173
BMET217
BGLU273
BHIS307
BARG481
BTHR538
BMET583
BGLU639
BHIS671
AMET217
BARG744
CSER173
CMET217
CGLU273
CHIS307
CARG481
CTHR538
CMET583
CGLU639
CHIS671
AGLU273
CARG744
DSER173
DMET217
DGLU273
DHIS307
DARG481
DTHR538
DMET583
DGLU639
DHIS671
AHIS307
DARG744
AARG481
ATHR538
AMET583
AGLU639
AHIS671

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P47860
ChainResidueDetails
ASER142
BSER142
CSER142
DSER142

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:33607258, ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER386
BSER386
CSER386
DSER386

site_idSWS_FT_FI6
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS395
DLYS395
DLYS486
DLYS688
ALYS486
ALYS688
BLYS395
BLYS486
BLYS688
CLYS395
CLYS486
CLYS688

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR651
BTYR651
CTYR651
DTYR651

site_idSWS_FT_FI8
Number of Residues4
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000250
ChainResidueDetails
ASER540
BSER540
CSER540
DSER540

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PDB entries from 2024-10-30

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