4XYJ

Crystal structure of human phosphofructokinase-1 in complex with ATP and Mg, Northeast Structural Genomics Consortium Target HR9275

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	ATP-dependent 6-phosphofructokinase, platelet type	polymer	812	89144.7	8	UniProt (Q01813) Pfam (PF00365)	Homo sapiens (Human)	PFK-P,6-phosphofructokinase type C,Phosphofructo-1-kinase isozyme C,PFK-C,Phosphohexokinase
2	AA, EA, I, KA, N... (E, F, A, G, B...)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	8	Chemie (ATP)
3	BA, CA, FA, GA, J... (E, F, A, G, B...)	MAGNESIUM ION	non-polymer		24.3	15	Chemie (MG)
4	DA, HA, IA, L, M... (E, F, A, G, B...)	PHOSPHATE ION	non-polymer		95.0	12	Chemie (PO4)
5	JA, S (F, B)	COBALT (II) ION	non-polymer		58.9	2	Chemie (CO)
6	AB, TA, UA, VA, WA... (H, A, B, C, D...)	water	water		18.0	145	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 784 (UniProt: Q01813)

PDB	External Database	Details
Met -27	-	initiating methionine
Ser -26	-	expression tag
Tyr -25	-	expression tag
Tyr -24	-	expression tag
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
Asp -17	-	expression tag
Tyr -16	-	expression tag
Asp -15	-	expression tag
Ile -14	-	expression tag
Pro -13	-	expression tag
Thr -12	-	expression tag
Thr -11	-	expression tag
Glu -10	-	expression tag
Asn -9	-	expression tag
Leu -8	-	expression tag
Tyr -7	-	expression tag
Phe -6	-	expression tag
Gln -5	-	expression tag
Gly -4	-	expression tag
Ala -3	-	expression tag
Met -2	-	expression tag
Asp -1	-	expression tag
Pro 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	713157.8
Non-Polymers*	Number of molecules	37
	Total formula weight	5679.5
All*	Total formula weight	718837.4

*Water molecules are not included.