4XXW

Crystal structure of mouse Cadherin-23 EC1-2 and Protocadherin-15 EC1-2 splice variant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Protocadherin-15	polymer	237	26780.9	2	UniProt (Q99PJ1) Pfam (PF18432) Pfam (PF00028)	Mus musculus (Mouse)
2	C, D (C, D)	Cadherin-23	polymer	214	23856.4	2	UniProt (Q99PF4) Pfam (PF00028)	Mus musculus (Mouse)	Otocadherin
3	E, F, G, I, J... (B, A, C, D)	CALCIUM ION	non-polymer		40.1	14	Chemie (CA)
4	H, L (B, A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	U, V, W, X (B, A, C, D)	water	water		18.0	463	Chemie (HOH)

Sequence modifications

B, A: 6 - 233 (UniProt: Q99PJ1)

PDB	External Database	Details
Met 5	-	initiating methionine
Leu 234	-	expression tag
Glu 235	-	expression tag
His 236	-	expression tag
His 237	-	expression tag
His 238	-	expression tag
His 239	-	expression tag
His 240	-	expression tag
His 241	-	expression tag

C, D: 1 - 205 (UniProt: Q99PF4)

PDB	External Database	Details
Met 0	-	initiating methionine
Leu 206	-	expression tag
Glu 207	-	expression tag
His 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	101274.7
Non-Polymers*	Number of molecules	16
	Total formula weight	632.0
All*	Total formula weight	101906.7

*Water molecules are not included.