4XSE

Complex structure of thymidylate synthase from varicella zoster virus

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C, B, D, A	Thymidylate synthase	polymer	311	35768.8	4	UniProt (Q4JQW2) Pfam (PF00303) In PDB	Varicella-zoster virus (strain Oka vaccine) (HHV-3)	TSase
2	B, D, A	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)

Sequence modifications

C, B, D, A: 8 - 295 (UniProt: Q4JQW2)

PDB	External Database	Details
Met -15	-	initiating methionine
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
Ser -8	-	expression tag
Ser -7	-	expression tag
Gly -6	-	expression tag
Val -5	-	expression tag
Asp -4	-	expression tag
Leu -3	-	expression tag
Gly -2	-	expression tag
Thr -1	-	expression tag
Glu 0	-	expression tag
Asn 1	-	expression tag
Leu 2	-	expression tag
Tyr 3	-	expression tag
Phe 4	-	expression tag
Gln 5	-	expression tag
Ser 6	-	expression tag
Met 7	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	143075.4
Non-Polymers*	Number of molecules	4
	Total formula weight	379.9
All*	Total formula weight	143455.3

*Water molecules are not included.