4XSE

Complex structure of thymidylate synthase from varicella zoster virus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004146	molecular_function	dihydrofolate reductase activity
A	0004799	molecular_function	thymidylate synthase activity
A	0005829	cellular_component	cytosol
A	0006231	biological_process	dTMP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0008168	molecular_function	methyltransferase activity
A	0009165	biological_process	nucleotide biosynthetic process
A	0016741	molecular_function	transferase activity, transferring one-carbon groups
A	0032259	biological_process	methylation
B	0004146	molecular_function	dihydrofolate reductase activity
B	0004799	molecular_function	thymidylate synthase activity
B	0005829	cellular_component	cytosol
B	0006231	biological_process	dTMP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0008168	molecular_function	methyltransferase activity
B	0009165	biological_process	nucleotide biosynthetic process
B	0016741	molecular_function	transferase activity, transferring one-carbon groups
B	0032259	biological_process	methylation
C	0004146	molecular_function	dihydrofolate reductase activity
C	0004799	molecular_function	thymidylate synthase activity
C	0005829	cellular_component	cytosol
C	0006231	biological_process	dTMP biosynthetic process
C	0006235	biological_process	dTTP biosynthetic process
C	0008168	molecular_function	methyltransferase activity
C	0009165	biological_process	nucleotide biosynthetic process
C	0016741	molecular_function	transferase activity, transferring one-carbon groups
C	0032259	biological_process	methylation
D	0004146	molecular_function	dihydrofolate reductase activity
D	0004799	molecular_function	thymidylate synthase activity
D	0005829	cellular_component	cytosol
D	0006231	biological_process	dTMP biosynthetic process
D	0006235	biological_process	dTTP biosynthetic process
D	0008168	molecular_function	methyltransferase activity
D	0009165	biological_process	nucleotide biosynthetic process
D	0016741	molecular_function	transferase activity, transferring one-carbon groups
D	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PO4 B 1001

Chain	Residue
A	ARG38
A	ARG203
A	SER204
B	ARG163
B	ARG164

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site_id	AC2
Number of Residues	5
Details	binding site for residue PO4 D 1001

Chain	Residue
D	ARG164
C	LEU180
C	ARG203
C	SER204
D	ARG163

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site_id	AC3
Number of Residues	4
Details	binding site for residue PO4 D 1002

Chain	Residue
C	ARG163
D	ARG38
D	ARG203
D	SER204

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site_id	AC4
Number of Residues	6
Details	binding site for residue PO4 A 1001

Chain	Residue
A	ARG163
A	ARG164
B	ARG38
B	LEU180
B	ARG203
B	SER204

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Functional Information from PROSITE/UniProt

site_id	PS00091
Number of Residues	29
Details	THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrmIissWNpkdiplmv.....LpPCHtlcQFyV

Chain	Residue	Details
C	ARG163-VAL191

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P0A884

Chain	Residue	Details
C	CYS183
B	CYS183
D	CYS183
A	CYS183

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site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: in other chain => ECO:0000250|UniProtKB:P0A884

Chain	Residue	Details
D	ARG38
D	ARG203
D	ASN214
D	HIS244
A	ARG38
A	ARG203
A	ASN214
A	HIS244
C	ARG38
C	ARG203
C	ASN214
C	HIS244
B	ARG38
B	ARG203
B	ASN214
B	HIS244

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0A884

Chain	Residue	Details
D	ARG163
D	ASP206
A	ARG163
A	ASP206
C	ARG163
C	ASP206
B	ARG163
B	ASP206

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