4XSE
Complex structure of thymidylate synthase from varicella zoster virus
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0032259 | biological_process | methylation |
B | 0004799 | molecular_function | thymidylate synthase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006231 | biological_process | dTMP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
B | 0032259 | biological_process | methylation |
C | 0004799 | molecular_function | thymidylate synthase activity |
C | 0005829 | cellular_component | cytosol |
C | 0006231 | biological_process | dTMP biosynthetic process |
C | 0006235 | biological_process | dTTP biosynthetic process |
C | 0008168 | molecular_function | methyltransferase activity |
C | 0009165 | biological_process | nucleotide biosynthetic process |
C | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
C | 0032259 | biological_process | methylation |
D | 0004799 | molecular_function | thymidylate synthase activity |
D | 0005829 | cellular_component | cytosol |
D | 0006231 | biological_process | dTMP biosynthetic process |
D | 0006235 | biological_process | dTTP biosynthetic process |
D | 0008168 | molecular_function | methyltransferase activity |
D | 0009165 | biological_process | nucleotide biosynthetic process |
D | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
D | 0032259 | biological_process | methylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue PO4 B 1001 |
Chain | Residue |
A | ARG38 |
A | ARG203 |
A | SER204 |
B | ARG163 |
B | ARG164 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue PO4 D 1001 |
Chain | Residue |
D | ARG164 |
C | LEU180 |
C | ARG203 |
C | SER204 |
D | ARG163 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue PO4 D 1002 |
Chain | Residue |
C | ARG163 |
D | ARG38 |
D | ARG203 |
D | SER204 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue PO4 A 1001 |
Chain | Residue |
A | ARG163 |
A | ARG164 |
B | ARG38 |
B | LEU180 |
B | ARG203 |
B | SER204 |
Functional Information from PROSITE/UniProt
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrmIissWNpkdiplmv.....LpPCHtlcQFyV |
Chain | Residue | Details |
C | ARG163-VAL191 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Nucleophile => ECO:0000250|UniProtKB:P0A884 |
Chain | Residue | Details |
C | CYS183 | |
B | CYS183 | |
D | CYS183 | |
A | CYS183 |
site_id | SWS_FT_FI2 |
Number of Residues | 16 |
Details | BINDING: in other chain => ECO:0000250|UniProtKB:P0A884 |
Chain | Residue | Details |
C | ARG38 | |
D | ARG203 | |
D | ASN214 | |
D | HIS244 | |
A | ARG38 | |
A | ARG203 | |
A | ASN214 | |
A | HIS244 | |
C | ARG203 | |
C | ASN214 | |
C | HIS244 | |
B | ARG38 | |
B | ARG203 | |
B | ASN214 | |
B | HIS244 | |
D | ARG38 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0A884 |
Chain | Residue | Details |
C | ARG163 | |
C | ASP206 | |
B | ARG163 | |
B | ASP206 | |
D | ARG163 | |
D | ASP206 | |
A | ARG163 | |
A | ASP206 |