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4XP6

X-ray structure of Drosophila dopamine transporter bound to psychostimulant methamphetamine

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Transporterpolymer53459892.31UniProt (A0A0B4KEX2)
Pfam (PF00209)
UniProt (by SIFTS) (Q7K4Y6)
Drosophila melanogaster (Fruit fly)
2B
(L)
Antibody fragment heavy chain-protein, 9D5-heavy chainpolymer21323177.51Mus musculus
3C
(H)
Antibody fragment light chain-protein, 9D5-light chainpolymer21923619.41Mus musculus
4D
(B)
alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranosebranched342.31In PDB
BIRD (PRD_900001)
GlyTouCan (G07411ON)
alpha-maltose
5E
(A)
(2S)-N-methyl-1-phenylpropan-2-aminenon-polymer149.21Chemie (B40)
6F, G
(A)
SODIUM IONnon-polymer23.02Chemie (NA)
7H
(A)
CHLORIDE IONnon-polymer35.51Chemie (CL)
8I
(A)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.21Chemie (NAG)
9J
(A)
CHOLESTEROLnon-polymer386.71Chemie (CLR)
10K
(A)
CHOLESTEROL HEMISUCCINATEnon-polymer486.71Chemie (Y01)
11L, M, N
(A, L, H)
waterwater18.022Chemie (HOH)
Sequence modifications
A: 25 - 599 (UniProt: A0A0B4KEX2)
PDBExternal DatabaseDetails
Ala 74Val 74engineered mutation
-Ser 162deletion
-Gln 163deletion
-Asn 164deletion
-Ala 165deletion
-Ser 166deletion
-Arg 167deletion
-Val 168deletion
-Pro 169deletion
-Val 170deletion
-Ile 171deletion
-Gly 172deletion
-Asn 173deletion
-Tyr 174deletion
-Ser 175deletion
-Asp 176deletion
-Leu 177deletion
-Tyr 178deletion
-Ala 179deletion
-Met 180deletion
-Gly 181deletion
-Asn 182deletion
-Gln 183deletion
-Ser 184deletion
-Leu 185deletion
-Leu 186deletion
-Tyr 187deletion
-Asn 188deletion
-Glu 189deletion
-Thr 190deletion
-Tyr 191deletion
-Met 192deletion
-Asn 193deletion
-Gly 194deletion
-Ser 195deletion
-Ser 196deletion
-Leu 197deletion
-Asp 198deletion
-Thr 199deletion
-Ser 200deletion
-Ala 201deletion
-Val 202deletion
Ala 415Leu 415engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight106689.2
BranchedNumber of molecules1
Total formula weight342.3
Non-Polymers*Number of molecules7
Total formula weight1325.3
All*Total formula weight108356.7
*Water molecules are not included.

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PDB entries from 2024-11-06

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