4XFS
Structure of IL-18 SER Mutant I
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Interleukin-18 | polymer | 157 | 17965.4 | 2 | UniProt (Q14116) Pfam (PF00340) In PDB | Homo sapiens (Human) | IL-18,Iboctadekin,Interferon gamma-inducing factor,IFN-gamma-inducing factor,Interleukin-1 gamma,IL-1 gamma |
| 2 | A, B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 5 | Chemie (DMS) | |||
| 3 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 157 (UniProt: Q14116)
| PDB | External Database | Details |
|---|---|---|
| Ala 139 | Lys 175 | engineered mutation |
| Ala 140 | Lys 176 | engineered mutation |
| Ala 141 | Glu 177 | engineered mutation |
| Ala 143 | Glu 179 | engineered mutation |
| Ala 144 | Leu 180 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35930.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 574.9 | |
| All* | Total formula weight | 36505.6 |
