4XFS
Structure of IL-18 SER Mutant I
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006954 | biological_process | inflammatory response |
| A | 0006955 | biological_process | immune response |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005615 | cellular_component | extracellular space |
| B | 0006954 | biological_process | inflammatory response |
| B | 0006955 | biological_process | immune response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 201 |
| Chain | Residue |
| A | GLN114 |
| A | PHE124 |
| A | ASP142 |
| A | ALA143 |
| A | ALA144 |
| A | ILE149 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue DMS A 202 |
| Chain | Residue |
| A | ASN155 |
| B | HIS109 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 203 |
| Chain | Residue |
| A | LYS8 |
| A | LEU9 |
| A | ALA144 |
| A | GLY145 |
| A | GLU156 |
| A | SER7 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 204 |
| Chain | Residue |
| A | ARG58 |
| A | GLY59 |
| A | ARG104 |
| B | ARG58 |
| B | GLY59 |
| B | ARG104 |
| B | HOH307 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 201 |
| Chain | Residue |
| B | GLN114 |
| B | ASP142 |
| B | ALA143 |
| B | ALA144 |
| B | ILE149 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue DMS B 202 |
| Chain | Residue |
| B | ASP146 |
| B | HOH312 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 203 |
| Chain | Residue |
| B | LYS70 |
| B | ILE71 |
| B | ASN87 |
| B | ALA140 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Site: {"description":"Cleavage; by CASP3","evidences":[{"source":"PubMed","id":"37993714","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9334240","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
