4XDE

Coagulation Factor XII protease domain crystal structure

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Coagulation factor XII	polymer	257	27877.2	1	UniProt (P00748) Pfam (PF00089)	Homo sapiens (Human)	Hageman factor,HAF
2	B, C (A)	ISOPROPYL ALCOHOL	non-polymer		60.1	2	Chemie (IPA)
3	D (A)	CITRATE ANION	non-polymer		189.1	1	Chemie (FLC)
4	E (A)	water	water		18.0	97	Chemie (HOH)

Sequence modifications

A: 354 - 596 (UniProt: P00748)

PDB	External Database	Details
Arg 352	-	expression tag
Ser 353	-	expression tag
Ser 467	Cys 486	engineered mutation
His 597	-	expression tag
His 598	-	expression tag
Thr 599	-	expression tag
Gly 600	-	expression tag
Thr 601	-	expression tag
Arg 602	-	expression tag
His 603	-	expression tag
His 604	-	expression tag
His 605	-	expression tag
His 606	-	expression tag
His 607	-	expression tag
His 608	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	27877.2
Non-Polymers*	Number of molecules	3
	Total formula weight	309.3
All*	Total formula weight	28186.5

*Water molecules are not included.