4XAQ

mGluR2 ECD and mGluR3 ECD with ligands

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Metabotropic glutamate receptor 2	polymer	503	55712.8	2	UniProt (Q14416) Pfam (PF01094)	Homo sapiens (Human)	mGluR2
2	C, G (A, B)	(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid	non-polymer		185.2	2	Chemie (40F) PubChem (114827) PubChem (213056) PubChem (6101858) PubChem (10702665) PubChem (10845212) PubChem (44322702) PubChem (45098631) PubChem (50989828) PubChem (156666) PubChem (15408708) PubChem (89156372) PubChem (89651893) PubChem (90488818) PubChem (90936348) PubChem (90981390) PubChem (92403463) PubChem (98137211) PubChem (99722638) PubChem (99722640) PubChem (101932822) PubChem (102066259) PubChem (121226785) PubChem (124560124) PubChem (130820172) PubChem (130976542) PubChem (131013715) PubChem (139025891) PubChem (146157633) PubChem (154825295)
3	D, H (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	E, F, I (A, B)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL) PubChem (312)
5	J, K (A, B)	water	water		18.0	527	Chemie (HOH)

Sequence modifications

A, B: 2 - 493 (UniProt: Q14416)

PDB	External Database	Details
Met -1	-	initiating methionine
Ala 0	-	expression tag
Leu 1	-	expression tag
Ser 234	Cys 234	conflict
Glu 302	Ser 302	conflict
Glu 494	-	expression tag
Gly 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	111425.7
Non-Polymers*	Number of molecules	7
	Total formula weight	668.8
All*	Total formula weight	112094.5

*Water molecules are not included.