4XAQ

mGluR2 ECD and mGluR3 ECD with ligands

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Metabotropic glutamate receptor 2	polymer	503	55712.8	2	UniProt (Q14416) Pfam (PF01094)	Homo sapiens (Human)	mGluR2
2	C, G (A, B)	(1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid	non-polymer		185.2	2	Chemie (40F)
3	D, H (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	E, F, I (A, B)	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
5	J, K (A, B)	water	water		18.0	527	Chemie (HOH)

Sequence modifications

A, B: 2 - 493 (UniProt: Q14416)

PDB	External Database	Details
Met -1	-	initiating methionine
Ala 0	-	expression tag
Leu 1	-	expression tag
Ser 234	Cys 234	conflict
Glu 302	Ser 302	conflict
Glu 494	-	expression tag
Gly 495	-	expression tag
His 496	-	expression tag
His 497	-	expression tag
His 498	-	expression tag
His 499	-	expression tag
His 500	-	expression tag
His 501	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	111425.7
Non-Polymers*	Number of molecules	7
	Total formula weight	668.8
All*	Total formula weight	112094.5

*Water molecules are not included.