4X99

Immunoglobulin Fc heterodimers variant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ig gamma-1 chain C region	polymer	223	25094.4	1	UniProt (P01857) Pfam (PF07654)	Homo sapiens (Human)
2	B (B)	Ig gamma-1 chain C region	polymer	223	25080.5	1	UniProt (P01857) Pfam (PF07654)	Homo sapiens (Human)
3	C, D (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1463.3	2	In PDB GlyTouCan (G80858MF)
4	E, F (A, B)	water	water		18.0	41	Chemie (HOH)

Sequence modifications

A: 225 - 447 (UniProt: P01857)

PDB	External Database	Details
Cys 349	Tyr 232	engineered mutation
Glu 360	Lys 243	engineered mutation
Trp 409	Lys 292	engineered mutation

B: 225 - 447 (UniProt: P01857)

PDB	External Database	Details
Arg 347	Gln 230	engineered mutation
Cys 354	Ser 237	engineered mutation
Val 399	Asp 282	engineered mutation
Thr 405	Phe 288	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50174.9
Branched	Number of molecules	2
	Total formula weight	2926.7
All*	Total formula weight	53101.6

*Water molecules are not included.