4X98

Immunoglobulin Fc heterodimer variant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ig gamma-1 chain C region	polymer	220	24871.1	1	UniProt (P01857) Pfam (PF07654)	Homo sapiens (Human)
2	B (B)	Ig gamma-1 chain C region	polymer	207	23544.7	1	UniProt (P01857) Pfam (PF07654)	Homo sapiens (Human)
3	C, D (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1463.3	2	In PDB GlyTouCan (G80858MF)
4	E, F (A, B)	water	water		18.0	71	Chemie (HOH)

Sequence modifications

A: 225 - 444 (UniProt: P01857)

PDB	External Database	Details
Glu 360	Lys 243	engineered mutation
Trp 409	Lys 292	engineered mutation

B: 238 - 444 (UniProt: P01857)

PDB	External Database	Details
Arg 347	Gln 230	engineered mutation
Val 399	Asp 282	engineered mutation
Thr 405	Phe 288	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48415.7
Branched	Number of molecules	2
	Total formula weight	2926.7
All*	Total formula weight	51342.4

*Water molecules are not included.