4X6R
An Isoform-specific Myristylation Switch Targets RIIb PKA Holoenzymes to Membranes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 350 | 40711.3 | 1 | UniProt (P05132) Pfam (PF00069) | Mus musculus (Mouse) | PKA C-alpha |
| 2 | B (B) | cAMP-dependent protein kinase type I-alpha regulatory subunit | polymer | 290 | 32652.1 | 1 | UniProt (P00514) Pfam (PF00027) | Bos taurus (Bovine) | |
| 3 | C, H, K, L, M... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | D (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 5 | E (A) | TRIS(HYDROXYETHYL)AMINOMETHANE | non-polymer | 163.2 | 1 | Chemie (TAM) | |||
| 6 | F, O (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | G (A) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
| 8 | I, J (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 9 | P, Q (A, B) | water | water | 18.0 | 269 | Chemie (HOH) |
Sequence modifications
A: 1 - 350 (UniProt: P05132)
B: 90 - 379 (UniProt: P00514)
| PDB | External Database | Details |
|---|---|---|
| Cys 7 | Lys 8 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Lys 333 | Arg 334 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73363.3 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1707.9 | |
| All* | Total formula weight | 75071.3 |
