4X6J
Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cathepsin K | polymer | 215 | 23523.5 | 1 | UniProt (P43235) Pfam (PF00112) | Homo sapiens (Human) | Cathepsin O,Cathepsin O2,Cathepsin X |
| 2 | B (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | E, F, G (A) | S-1,2-PROPANEDIOL | non-polymer | 76.1 | 3 | Chemie (PGO) | |||
| 6 | H (A) | 2-amino-4-chloro-N-(1-{[(2E)-2-iminoethyl]carbamoyl}cyclohexyl)benzamide | non-polymer | 336.8 | 1 | Chemie (3Y2) | |||
| 7 | I (A) | water | water | 18.0 | 230 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23523.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 731.7 | |
| All* | Total formula weight | 24255.2 |
