Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

4X6J

Development of N-(Functionalized benzoyl)-homocycloleucyl-glycinonitriles as Potent Cathepsin K Inhibitors.

Functional Information from GO Data
ChainGOidnamespacecontents
A0006508biological_processproteolysis
A0008234molecular_functioncysteine-type peptidase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue GOL A 301
ChainResidue
ASER58
ACL302
AHOH435
AHOH447
AHOH502

site_idAC2
Number of Residues3
Detailsbinding site for residue CL A 302
ChainResidue
ACYS96
AGOL301
AHOH402

site_idAC3
Number of Residues4
Detailsbinding site for residue K A 303
ChainResidue
AALA197
AALA203
AHOH551
AMET196

site_idAC4
Number of Residues4
Detailsbinding site for residue PGO A 304
ChainResidue
AARG8
ATYR193
AHOH422
AHOH508

site_idAC5
Number of Residues5
Detailsbinding site for residue PGO A 305
ChainResidue
AARG8
AVAL13
ATHR14
APRO15
ATYR193

site_idAC6
Number of Residues5
Detailsbinding site for residue PGO A 306
ChainResidue
APRO88
ATYR89
AVAL90
ALYS200
AHOH440

site_idAC7
Number of Residues12
Detailsbinding site for residue 3Y2 A 307
ChainResidue
AGLN19
AGLY23
ACYS25
ATRP26
AGLY64
AGLY65
AGLY66
ALEU160
AASN161
AHOH493
AHOH517
AHOH544

Functional Information from PROSITE/UniProt
site_idPS00139
Number of Residues12
DetailsTHIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSS
ChainResidueDetails
AGLN19-SER30

site_idPS00639
Number of Residues11
DetailsTHIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. LNHAVLAVGYG
ChainResidueDetails
ALEU160-GLY170

site_idPS00640
Number of Residues20
DetailsTHIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. HWIiKNSWgenWGnkGYIlM
ChainResidueDetails
AHIS177-MET196

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: ACT_SITE => ECO:0000250
ChainResidueDetails
ACYS25
AHIS162
AASN182

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon