4X5X

HLA-DR1 mutant bN82A with covalently linked CLIP106-120(M107W)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	HLA class II histocompatibility antigen, DR alpha chain	polymer	193	22353.2	2	UniProt (P01903) Pfam (PF00993) Pfam (PF07654)	Homo sapiens (Human)	MHC class II antigen DRA
2	B, D (B, D)	HLA class II histocompatibility antigen, DRB1-1 beta chain	polymer	229	25761.9	2	UniProt (P04229) Pfam (PF00969) Pfam (PF07654) UniProt (by SIFTS) (P01911)	Homo sapiens (Human)	MHC class II antigen DRB1*1,DR1

Sequence modifications

A, C: 1 - 192 (UniProt: P01903)

PDB	External Database	Details
Met 0	-	initiating methionine

B, D: 1 - 198 (UniProt: P04229)

PDB	External Database	Details
Met -30	-	initiating methionine
Lys -29	-	expression tag
Trp -28	-	expression tag
Arg -27	-	expression tag
Met -26	-	expression tag
Ala -25	-	expression tag
Thr -24	-	expression tag
Pro -23	-	expression tag
Leu -22	-	expression tag
Leu -21	-	expression tag
Met -20	-	expression tag
Gln -19	-	expression tag
Ala -18	-	expression tag
Leu -17	-	expression tag
Pro -16	-	expression tag
Met -15	-	expression tag
Gly -14	-	expression tag
Gly -13	-	expression tag
Gly -12	-	expression tag
Gly -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Ser -5	-	expression tag
Gly -4	-	expression tag
Gly -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ala 82	Asn 111	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	96230.2
All*	Total formula weight	96230.2

*Water molecules are not included.