4WYM

Structural basis of HIV-1 capsid recognition by CPSF6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Capsid protein p24	polymer	231	25461.3	12	UniProt (P12497) Pfam (PF00607) Pfam (PF19317) UniProt (by SIFTS) (P12493) In PDB	Human immunodeficiency virus type 1 group M subtype B (HIV-1)	Pr55Gag
2	M, N, O, P, Q...	ISOFORM 2 OF CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 6	polymer	17	1709.0	11	UniProt (Q16630) In PDB	Homo sapiens (Human)	Cleavage and polyadenylation specificity factor 68 kDa subunit,CPSF 68 kDa subunit,Pre-mRNA cleavage factor Im 68 kDa subunit,Protein HPBRII-4/7

Sequence modifications

A, B, C, D, E, F, G, H, I, J, K, L: 1 - 231 (UniProt: P12497)

PDB	External Database	Details
Cys 14	Ala 146	engineered mutation
Cys 45	Glu 177	engineered mutation
Ala 184	Trp 316	engineered mutation
Ala 185	Met 317	engineered mutation

M, N, O, P, Q, R, S, T, U, V, W: 313 - 327 (UniProt: Q16630)

PDB	External Database	Details
Gly 311	-	expression tag
Thr 312	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	23
	Total formula weight	324333.7
All*	Total formula weight	324333.7

*Water molecules are not included.