4WXV
Human cationic trypsin K97D mutant in complex with bovine pancreatic trypsin inhibitor (BPTI)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Trypsin-1 | polymer | 224 | 24088.1 | 2 | UniProt (P07477) Pfam (PF00089) | Homo sapiens (Human) | Beta-trypsin,Cationic trypsinogen,Serine protease 1,Trypsin I |
| 2 | C, D (C, I) | Pancreatic trypsin inhibitor | polymer | 55 | 6342.4 | 2 | UniProt (P00974) Pfam (PF00014) | Bos taurus (Bovine) | Aprotinin,Basic protease inhibitor,BPTI |
| 3 | E, F (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 4 | G, H, I, J (C, I) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | K, L, M, N (A, B, C, I) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
A, B: 16 - 246 (UniProt: P07477)
| PDB | External Database | Details |
|---|---|---|
| Asp 97 | Lys 102 | engineered mutation |
| His 117 | Arg 122 | engineered mutation |
| Ala 195 | Ser 200 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60860.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 464.4 | |
| All* | Total formula weight | 61325.3 |
