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4WVD

Identification of a novel FXR ligand that regulates metabolism

Replaces:  4II6
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1C, DNuclear receptor corepressor 1polymer171866.22UniProt (O75376)
In PDB
Homo sapiensN-CoR1
2A, BBile acid receptorpolymer21124604.32UniProt (Q96RI1)
Pfam (PF00104)
In PDB
Homo sapiens (Human)Farnesoid X-activated receptor,Farnesol receptor HRR-1,Nuclear receptor subfamily 1 group H member 4,Retinoid X receptor-interacting protein 14,RXR-interacting protein 14
3A, BFORMIC ACIDnon-polymer46.08Chemie (FMT)
4A, B(2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranosidenon-polymer875.12Chemie (IVM)
5waterwater18.011Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight52940.9
Non-Polymers*Number of molecules10
Total formula weight2118.4
All*Total formula weight55059.3
*Water molecules are not included.

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PDB entries from 2024-07-17

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