4WTI
CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-ACGG, RNA PRIMER 5'-PCC, MN2+, AND GDP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | T | RNA TEMPLATE ACGG | polymer | 4 | 1279.8 | 1 | synthetic construct | ||
2 | P | RNA PRIMER CC | polymer | 2 | 565.4 | 1 | synthetic construct | ||
3 | A | RNA-directed RNA polymerase | polymer | 580 | 64819.4 | 1 | UniProt (Q99IB8) Pfam (PF00998) In PDB | Hepatitis C virus JFH-1 | |
4 | A | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
5 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
6 | A | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
7 | A | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 1 | Chemie (B3P) | |||
8 | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
A: 1 - 570 (UniProt: Q99IB8)
PDB | External Database | Details |
---|---|---|
Met -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 15 | Ser 2457 | engineered mutation |
Gln 86 | Glu 2528 | engineered mutation |
Gln 87 | Glu 2529 | engineered mutation |
His 223 | Cys 2665 | engineered mutation |
Ile 321 | Val 2763 | engineered mutation |
Leu 571 | - | expression tag |
Glu 572 | - | expression tag |
His 573 | - | expression tag |
His 574 | - | expression tag |
His 575 | - | expression tag |
His 576 | - | expression tag |
His 577 | - | expression tag |
His 578 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 66664.6 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 925.8 | |
All* | Total formula weight | 67590.4 |