4WS2

Crystal structure of Mycobacterium tuberculosis uracil-DNA glycosylase in complex with 6-aminouracil, Form I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Uracil-DNA glycosylase	polymer	238	25813.5	1	UniProt (P9WFQ9) Pfam (PF03167)	Mycobacterium tuberculosis	UDG
2	B, C (A)	CITRIC ACID	non-polymer		192.1	2	Chemie (CIT)
3	D (A)	6-aminopyrimidine-2,4(3H,5H)-dione	non-polymer		127.1	1	Chemie (6UA)
4	E, F, G, H, I (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	5	Chemie (DMS)
5	J (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	K (A)	ISOPROPYL ALCOHOL	non-polymer		60.1	1	Chemie (IPA)
7	L (A)	water	water		18.0	338	Chemie (HOH)

Sequence modifications

A: 1 - 227 (UniProt: P9WFQ9)

PDB	External Database	Details
Met -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Gly -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	25813.5
Non-Polymers*	Number of molecules	10
	Total formula weight	997.6
All*	Total formula weight	26811.1

*Water molecules are not included.