4WRL
Structure of the human CSF-1:CSF-1R complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Macrophage colony-stimulating factor 1 receptor | polymer | 286 | 31583.9 | 2 | UniProt (P07333) Pfam (PF00047) In PDB | Homo sapiens (Human) | CSF-1 receptor,M-CSF-R,Proto-oncogene c-Fms |
2 | B, D | Macrophage colony-stimulating factor 1 | polymer | 170 | 19757.3 | 2 | UniProt (P09603) Pfam (PF05337) In PDB | Homo sapiens (Human) | MCSF,Lanimostim |
3 | E, H | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 820.7 | 2 | In PDB GlyTouCan (G43476MN) | |||
4 | F | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 383.3 | 1 | In PDB GlyTouCan (G00055MO) | |||
5 | G, I | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 674.6 | 2 | In PDB BIRD (PRD_900067) GlyTouCan (G00065MO) | 3'-sialyl-N-acetyllactosamine | ||
6 | A | N-acetyl-alpha-neuraminic acid | non-polymer | 309.3 | 1 | Chemie (SIA) | |||
7 | A, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A, C: 20 - 296 (UniProt: P07333)
B, D: 1 - 149 (UniProt: P09603)
PDB | External Database | Details |
---|---|---|
Gln 240 | Asn 240 | engineered mutation |
Gly 297 | - | expression tag |
Thr 298 | - | expression tag |
Lys 299 | - | expression tag |
His 300 | - | expression tag |
His 301 | - | expression tag |
His 302 | - | expression tag |
His 303 | - | expression tag |
His 304 | - | expression tag |
His 305 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -20 | - | initiating methionine |
Gly -19 | - | expression tag |
Ser -18 | - | expression tag |
Ser -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Ser -10 | - | expression tag |
Ser -9 | - | expression tag |
Gly -8 | - | expression tag |
Leu -7 | - | expression tag |
Val -6 | - | expression tag |
Pro -5 | - | expression tag |
Arg -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
His -1 | - | expression tag |
Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 102682.4 | |
Branched | Number of molecules | 5 |
Total formula weight | 3374.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 972.9 | |
All* | Total formula weight | 107029.3 |