4WOH
Structure of of human dual-specificity phosphatase 22 (E24A/K28A/K30A/C88S) complexed with 4-nitrophenolphosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity protein phosphatase 22 | polymer | 166 | 18548.0 | 1 | UniProt (Q9NRW4) Pfam (PF00782) | Homo sapiens (Human) | JNK-stimulatory phosphatase-1,JSP-1,Low molecular weight dual specificity phosphatase 2,LMW-DSP2,Mitogen-activated protein kinase phosphatase x,MKP-x |
| 2 | B (A) | 4-NITROPHENYL PHOSPHATE | non-polymer | 219.1 | 1 | Chemie (4NP) | |||
| 3 | C (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 4 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E (A) | water | water | 18.0 | 193 | Chemie (HOH) |
Sequence modifications
A: 1 - 163 (UniProt: Q9NRW4)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Ala 24 | Glu 24 | engineered mutation |
| Ala 28 | Lys 28 | engineered mutation |
| Ala 30 | Lys 30 | engineered mutation |
| Ser 88 | Cys 88 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18548.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 387.3 | |
| All* | Total formula weight | 18935.3 |
