4WOH
Structure of of human dual-specificity phosphatase 22 (E24A/K28A/K30A/C88S) complexed with 4-nitrophenolphosphate
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 4NP A 201 |
| Chain | Residue |
| A | LYS7 |
| A | VAL92 |
| A | SER93 |
| A | ARG94 |
| A | ILE8 |
| A | LEU9 |
| A | PRO10 |
| A | ASP57 |
| A | SER88 |
| A | LEU89 |
| A | ALA90 |
| A | GLY91 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 202 |
| Chain | Residue |
| A | ALA30 |
| A | VAL31 |
| A | THR32 |
| A | HOH315 |
| A | HOH428 |
| A | HOH444 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 203 |
| Chain | Residue |
| A | ASP108 |
| A | GLY110 |
| A | ARG147 |
| A | HOH316 |
| A | HOH326 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 140 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17068812","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"25664796","evidenceCode":"ECO:0000303"},{"source":"PubMed","id":"33053837","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25664796","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4WOH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"PubMed","id":"20553486","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
