4WMU
STRUCTURE OF MBP-MCL1 BOUND TO ligand 2 AT 1.55A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MBP-MCL1 chimera protein,Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 518 | 57310.9 | 1 | UniProt (P0AEX9) UniProt (Q07820) Pfam (PF01547) Pfam (PF00452) | Escherichia coli | |
| 2 | B (B) | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 1 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
| 3 | C (A) | 6-chloro-3-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1H-indole-2-carboxylic acid | non-polymer | 392.3 | 1 | Chemie (19H) | |||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F, G, H, I, J... (A) | FORMIC ACID | non-polymer | 46.0 | 13 | Chemie (FMT) | |||
| 6 | S (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | T, U, V, W (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 8 | X (A) | water | water | 18.0 | 506 | Chemie (HOH) |
Sequence modifications
A: -195 - 170 (UniProt: P0AEX9)
A: 174 - 321 (UniProt: Q07820)
| PDB | External Database | Details |
|---|---|---|
| Gly -196 | - | expression tag |
| Gly 171 | - | linker |
| Ser 172 | - | linker |
| Glu 173 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 194 | Lys 194 | engineered mutation |
| Ala 197 | Lys 197 | engineered mutation |
| Ala 201 | Arg 201 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 57310.9 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 342.3 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 1310.5 | |
| All* | Total formula weight | 58963.7 |
