4WI4
Structural mapping of the human IgG1 binding site for FcRn: hu3S193 Fc mutation S254A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ig gamma-1 chain C region | polymer | 207 | 23561.6 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | C, D (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 2 | In PDB GlyTouCan (G80858MF) | |||
| 3 | E, F, G (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 33 | Chemie (HOH) |
Sequence modifications
A, B: 238 - 444 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Ala 254 | Ser 137 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47123.2 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2926.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 186.2 | |
| All* | Total formula weight | 50236.1 |
