4WHH
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase PLK1 | polymer | 237 | 27285.2 | 1 | UniProt (P53350) Pfam (PF00659) | Homo sapiens (Human) | Polo-like kinase 1,PLK-1,Serine/threonine-protein kinase 13,STPK13 |
| 2 | B (B) | C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR | polymer | 5 | 814.8 | 1 | BIRD (PRD_002127) | synthetic construct | |
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A: 371 - 603 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Gly 367 | - | expression tag |
| Ala 368 | - | expression tag |
| His 369 | - | expression tag |
| Met 370 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28100.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 192.1 | |
| All* | Total formula weight | 28292.1 |
