4WHH
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 701 |
Chain | Residue |
A | ASP438 |
A | THR517 |
A | ARG518 |
A | SER519 |
A | TYR582 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 702 |
Chain | Residue |
A | HOH830 |
A | ALA548 |
A | ARG557 |
A | ARG563 |
A | SER565 |
site_id | AC3 |
Number of Residues | 20 |
Details | BINDING SITE FOR CHAIN B OF C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR |
Chain | Residue |
A | GLU399 |
A | LYS413 |
A | TRP414 |
A | ASP416 |
A | TYR421 |
A | LEU463 |
A | THR464 |
A | TYR481 |
A | TYR485 |
A | LEU490 |
A | LEU491 |
A | ARG516 |
A | HIS538 |
A | LYS540 |
A | TYR570 |
B | HOH101 |
B | HOH102 |
B | HOH103 |
B | HOH104 |
B | HOH105 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976 |
Chain | Residue | Details |
A | SER375 | |
A | SER450 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976 |
Chain | Residue | Details |
A | THR498 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23455478 |
Chain | Residue | Details |
A | LYS492 |