4WHH
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 701 |
| Chain | Residue |
| A | ASP438 |
| A | THR517 |
| A | ARG518 |
| A | SER519 |
| A | TYR582 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 702 |
| Chain | Residue |
| A | HOH830 |
| A | ALA548 |
| A | ARG557 |
| A | ARG563 |
| A | SER565 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR CHAIN B OF C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR |
| Chain | Residue |
| A | GLU399 |
| A | LYS413 |
| A | TRP414 |
| A | ASP416 |
| A | TYR421 |
| A | LEU463 |
| A | THR464 |
| A | TYR481 |
| A | TYR485 |
| A | LEU490 |
| A | LEU491 |
| A | ARG516 |
| A | HIS538 |
| A | LYS540 |
| A | TYR570 |
| B | HOH101 |
| B | HOH102 |
| B | HOH103 |
| B | HOH104 |
| B | HOH105 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 78 |
| Details | Domain: {"description":"POLO box 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 82 |
| Details | Domain: {"description":"POLO box 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00154","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Region: {"description":"Important for interaction with phosphorylated proteins","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23455478","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
