4WHH
A New Class of Peptidomimetics Targeting the Polo-box Domain of Polo-like kinase 1
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 701 |
| Chain | Residue |
| A | ASP438 |
| A | THR517 |
| A | ARG518 |
| A | SER519 |
| A | TYR582 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 702 |
| Chain | Residue |
| A | HOH830 |
| A | ALA548 |
| A | ARG557 |
| A | ARG563 |
| A | SER565 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR CHAIN B OF C6H5(CH2)8-DERIVATIZED PEPTIDE INHIBITOR |
| Chain | Residue |
| A | GLU399 |
| A | LYS413 |
| A | TRP414 |
| A | ASP416 |
| A | TYR421 |
| A | LEU463 |
| A | THR464 |
| A | TYR481 |
| A | TYR485 |
| A | LEU490 |
| A | LEU491 |
| A | ARG516 |
| A | HIS538 |
| A | LYS540 |
| A | TYR570 |
| B | HOH101 |
| B | HOH102 |
| B | HOH103 |
| B | HOH104 |
| B | HOH105 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | SER375 | |
| A | SER450 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976 |
| Chain | Residue | Details |
| A | THR498 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23455478 |
| Chain | Residue | Details |
| A | LYS492 |
