4WCU

PDE4 complexed with inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	polymer	359	41281.6	4	UniProt (Q08499) Pfam (PF00233)	Homo sapiens (Human)	DPDE3,PDE43
2	E, H, K, N (A, B, C, D)	N-benzyl-2-{6-[(3,5-dichloropyridin-4-yl)acetyl]-2,3-dimethoxyphenoxy}acetamide	non-polymer		489.3	4	Chemie (3KQ)
3	F, I, L, O (A, B, C, D)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4	G, J, M, P (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
5	Q, R, S, T (A, B, C, D)	water	water		18.0	335	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	165126.5
Non-Polymers*	Number of molecules	12
	Total formula weight	2316.2
All*	Total formula weight	167442.7

*Water molecules are not included.