4WCU

PDE4 complexed with inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity
C	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
C	0007165	biological_process	signal transduction
C	0008081	molecular_function	phosphoric diester hydrolase activity
D	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
D	0007165	biological_process	signal transduction
D	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 3KQ A 500

Chain	Residue
A	MET273
A	HOH680
A	HOH693
A	ASP318
A	ILE336
A	MET337
A	PHE340
A	GLN369
A	PHE372
A	PHE432
A	GLN433

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	HIS164
A	HIS200
A	ASP201
A	ASP318

---

site_id	AC3
Number of Residues	2
Details	binding site for residue MG A 502

Chain	Residue
A	ASP201
A	HOH693

---

site_id	AC4
Number of Residues	12
Details	binding site for residue 3KQ B 500

Chain	Residue
B	THR271
B	MET273
B	ASP318
B	LEU319
B	ASN321
B	ILE336
B	MET357
B	GLN369
B	PHE372
B	ILE376
B	PHE432
B	GLN433

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 501

Chain	Residue
B	HIS164
B	HIS200
B	ASP201
B	ASP318

---

site_id	AC6
Number of Residues	1
Details	binding site for residue MG B 502

Chain	Residue
B	ASP201

---

site_id	AC7
Number of Residues	12
Details	binding site for residue 3KQ C 500

Chain	Residue
C	THR271
C	MET273
C	ASP318
C	LEU319
C	ASN321
C	ILE336
C	PHE340
C	GLN369
C	PHE372
C	PHE432
C	GLN433
C	HOH672

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN C 501

Chain	Residue
C	HIS164
C	HIS200
C	ASP201
C	ASP318

---

site_id	AC9
Number of Residues	1
Details	binding site for residue MG C 502

Chain	Residue
C	ASP201

---

site_id	AD1
Number of Residues	14
Details	binding site for residue 3KQ D 500

Chain	Residue
D	THR271
D	MET273
D	ASP318
D	LEU319
D	THR333
D	ILE336
D	PHE340
D	MET357
D	GLN369
D	PHE372
D	PHE432
D	GLN433
D	LEU436
D	HOH641

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN D 501

Chain	Residue
D	HIS164
D	HIS200
D	ASP201
D	ASP318

---

site_id	AD3
Number of Residues	1
Details	binding site for residue MG D 502

Chain	Residue
D	ASP201

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS200-PHE211

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q07343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)"}

Chain

Residue

Details

---