4WB6
Crystal structure of a L205R mutant of human cAMP-dependent protein kinase A (catalytic alpha subunit)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 350 | 40801.4 | 1 | UniProt (P17612) Pfam (PF00069) | Homo sapiens (Human) | PKA C-alpha |
| 2 | B (B) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 350 | 40801.4 | 1 | UniProt (P17612) Pfam (PF00069) | Homo sapiens (Human) | PKA C-alpha |
| 3 | C, D (I, J) | PKI (5-24) | polymer | 20 | 2226.4 | 2 | UniProt (by SIFTS) (P61925) | Homo sapiens | |
| 4 | E, H (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | F, G, I, J (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 6 | K, L, M, N (A, B, I, J) | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A: 1 - 350 (UniProt: P17612)
B: 1 - 350 (UniProt: P17612)
| PDB | External Database | Details |
|---|---|---|
| Arg 205 | Leu 206 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Arg 205 | Leu 206 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 86055.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1111.6 | |
| All* | Total formula weight | 87167.2 |
