Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

4WB6

Crystal structure of a L205R mutant of human cAMP-dependent protein kinase A (catalytic alpha subunit)

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0001669cellular_componentacrosomal vesicle
A0001707biological_processmesoderm formation
A0001843biological_processneural tube closure
A0002027biological_processregulation of heart rate
A0003091biological_processrenal water homeostasis
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004691molecular_functioncAMP-dependent protein kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005929cellular_componentcilium
A0005930cellular_componentaxoneme
A0005952cellular_componentcAMP-dependent protein kinase complex
A0006397biological_processmRNA processing
A0006468biological_processprotein phosphorylation
A0006611biological_processprotein export from nucleus
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0016020cellular_componentmembrane
A0016241biological_processregulation of macroautophagy
A0016301molecular_functionkinase activity
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0019221biological_processcytokine-mediated signaling pathway
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0030007biological_processintracellular potassium ion homeostasis
A0030145molecular_functionmanganese ion binding
A0031410cellular_componentcytoplasmic vesicle
A0031514cellular_componentmotile cilium
A0031594cellular_componentneuromuscular junction
A0031625molecular_functionubiquitin protein ligase binding
A0031669biological_processcellular response to nutrient levels
A0032024biological_processpositive regulation of insulin secretion
A0032703biological_processnegative regulation of interleukin-2 production
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034380biological_processhigh-density lipoprotein particle assembly
A0034605biological_processcellular response to heat
A0034704cellular_componentcalcium channel complex
A0035694biological_processmitochondrial protein catabolic process
A0036126cellular_componentsperm flagellum
A0038110biological_processinterleukin-2-mediated signaling pathway
A0038202biological_processTORC1 signaling
A0042995cellular_componentcell projection
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0044853cellular_componentplasma membrane raft
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0045667biological_processregulation of osteoblast differentiation
A0045722biological_processpositive regulation of gluconeogenesis
A0045879biological_processnegative regulation of smoothened signaling pathway
A0046827biological_processpositive regulation of protein export from nucleus
A0048240biological_processsperm capacitation
A0048471cellular_componentperinuclear region of cytoplasm
A0050766biological_processpositive regulation of phagocytosis
A0050804biological_processmodulation of chemical synaptic transmission
A0050850biological_processpositive regulation of calcium-mediated signaling
A0051726biological_processregulation of cell cycle
A0055117biological_processregulation of cardiac muscle contraction
A0061136biological_processregulation of proteasomal protein catabolic process
A0070062cellular_componentextracellular exosome
A0070417biological_processcellular response to cold
A0070613biological_processregulation of protein processing
A0071333biological_processcellular response to glucose stimulus
A0071374biological_processcellular response to parathyroid hormone stimulus
A0071377biological_processcellular response to glucagon stimulus
A0071872biological_processcellular response to epinephrine stimulus
A0086064biological_processcell communication by electrical coupling involved in cardiac conduction
A0097546cellular_componentciliary base
A0097700biological_processvascular endothelial cell response to laminar fluid shear stress
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099103molecular_functionchannel activator activity
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0106310molecular_functionprotein serine kinase activity
A1903779biological_processregulation of cardiac conduction
A1904262biological_processnegative regulation of TORC1 signaling
A1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
A1990044biological_processprotein localization to lipid droplet
A2000810biological_processregulation of bicellular tight junction assembly
B0000166molecular_functionnucleotide binding
B0000287molecular_functionmagnesium ion binding
B0001669cellular_componentacrosomal vesicle
B0001707biological_processmesoderm formation
B0001843biological_processneural tube closure
B0002027biological_processregulation of heart rate
B0003091biological_processrenal water homeostasis
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004691molecular_functioncAMP-dependent protein kinase activity
B0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005929cellular_componentcilium
B0005930cellular_componentaxoneme
B0005952cellular_componentcAMP-dependent protein kinase complex
B0006397biological_processmRNA processing
B0006468biological_processprotein phosphorylation
B0006611biological_processprotein export from nucleus
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0016020cellular_componentmembrane
B0016241biological_processregulation of macroautophagy
B0016301molecular_functionkinase activity
B0016607cellular_componentnuclear speck
B0016740molecular_functiontransferase activity
B0018105biological_processpeptidyl-serine phosphorylation
B0019221biological_processcytokine-mediated signaling pathway
B0019901molecular_functionprotein kinase binding
B0019904molecular_functionprotein domain specific binding
B0030007biological_processintracellular potassium ion homeostasis
B0030145molecular_functionmanganese ion binding
B0031410cellular_componentcytoplasmic vesicle
B0031514cellular_componentmotile cilium
B0031594cellular_componentneuromuscular junction
B0031625molecular_functionubiquitin protein ligase binding
B0031669biological_processcellular response to nutrient levels
B0032024biological_processpositive regulation of insulin secretion
B0032703biological_processnegative regulation of interleukin-2 production
B0034237molecular_functionprotein kinase A regulatory subunit binding
B0034380biological_processhigh-density lipoprotein particle assembly
B0034605biological_processcellular response to heat
B0034704cellular_componentcalcium channel complex
B0035694biological_processmitochondrial protein catabolic process
B0036126cellular_componentsperm flagellum
B0038110biological_processinterleukin-2-mediated signaling pathway
B0038202biological_processTORC1 signaling
B0042995cellular_componentcell projection
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0044853cellular_componentplasma membrane raft
B0045542biological_processpositive regulation of cholesterol biosynthetic process
B0045667biological_processregulation of osteoblast differentiation
B0045722biological_processpositive regulation of gluconeogenesis
B0045879biological_processnegative regulation of smoothened signaling pathway
B0046827biological_processpositive regulation of protein export from nucleus
B0048240biological_processsperm capacitation
B0048471cellular_componentperinuclear region of cytoplasm
B0050766biological_processpositive regulation of phagocytosis
B0050804biological_processmodulation of chemical synaptic transmission
B0050850biological_processpositive regulation of calcium-mediated signaling
B0051726biological_processregulation of cell cycle
B0055117biological_processregulation of cardiac muscle contraction
B0061136biological_processregulation of proteasomal protein catabolic process
B0070062cellular_componentextracellular exosome
B0070417biological_processcellular response to cold
B0070613biological_processregulation of protein processing
B0071333biological_processcellular response to glucose stimulus
B0071374biological_processcellular response to parathyroid hormone stimulus
B0071377biological_processcellular response to glucagon stimulus
B0071872biological_processcellular response to epinephrine stimulus
B0086064biological_processcell communication by electrical coupling involved in cardiac conduction
B0097546cellular_componentciliary base
B0097700biological_processvascular endothelial cell response to laminar fluid shear stress
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099103molecular_functionchannel activator activity
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0106310molecular_functionprotein serine kinase activity
B1903779biological_processregulation of cardiac conduction
B1904262biological_processnegative regulation of TORC1 signaling
B1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
B1990044biological_processprotein localization to lipid droplet
B2000810biological_processregulation of bicellular tight junction assembly
I0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
I0006469biological_processnegative regulation of protein kinase activity
J0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
J0006469biological_processnegative regulation of protein kinase activity
Functional Information from PDB Data
site_idAC1
Number of Residues28
Detailsbinding site for residue ATP A 401
ChainResidue
AGLY50
AMET120
AGLU121
AVAL123
AGLU127
AASP166
ALYS168
AGLU170
AASN171
ALEU173
ATHR183
AGLY52
AASP184
APHE327
AMG402
AMG403
AHOH514
AHOH523
AHOH583
IARG18
IALA21
ASER53
APHE54
AGLY55
AVAL57
AALA70
ALYS72
AVAL104

site_idAC2
Number of Residues4
Detailsbinding site for residue MG A 402
ChainResidue
AASN171
AASP184
AATP401
AHOH523

site_idAC3
Number of Residues4
Detailsbinding site for residue MG A 403
ChainResidue
AASP184
AATP401
AHOH524
AHOH583

site_idAC4
Number of Residues30
Detailsbinding site for residue ATP B 401
ChainResidue
BGLY50
BGLY52
BSER53
BPHE54
BGLY55
BVAL57
BALA70
BLYS72
BVAL104
BMET120
BGLU121
BVAL123
BGLU127
BASP166
BLYS168
BGLU170
BASN171
BLEU173
BTHR183
BASP184
BPHE327
BMG402
BMG403
BHOH513
BHOH535
BHOH540
BHOH575
JARG18
JASN20
JALA21

site_idAC5
Number of Residues4
Detailsbinding site for residue MG B 402
ChainResidue
BASN171
BASP184
BATP401
BHOH575

site_idAC6
Number of Residues4
Detailsbinding site for residue MG B 403
ChainResidue
BASP184
BATP401
BHOH535
BHOH540

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhketgnh..........YAMK
ChainResidueDetails
BLEU49-LYS72
ALEU49-LYS72

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
BLEU162-ILE174
ALEU162-ILE174

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsSITE: Important for inhibition => ECO:0000250
ChainResidueDetails
IARG15
IARG18
IARG19
JARG15
JARG18
JARG19

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING:
ChainResidueDetails
BLEU49

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
BLYS72
BGLU121
BLYS168

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Deamidated asparagine => ECO:0000250|UniProtKB:P05132
ChainResidueDetails
BASN2

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:P05132
ChainResidueDetails
BSEP10

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976
ChainResidueDetails
BTHR48

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P05132
ChainResidueDetails
BSER139

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:12372837
ChainResidueDetails
BTHR195

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:12372837, ECO:0000269|PubMed:16765046, ECO:0000269|PubMed:20137943, ECO:0000269|PubMed:20481595, ECO:0000269|PubMed:20732331, ECO:0000269|PubMed:21774789, ECO:0000269|Ref.43
ChainResidueDetails
BTPO197

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P05132
ChainResidueDetails
BTYR330

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:16765046, ECO:0000269|PubMed:20137943, ECO:0000269|PubMed:20481595, ECO:0000269|PubMed:20732331, ECO:0000269|PubMed:21774789, ECO:0000269|Ref.43, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569
ChainResidueDetails
BSEP338

site_idSWS_FT_FI12
Number of Residues1
DetailsLIPID: N-myristoyl glycine => ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:25807930
ChainResidueDetails
BGLY1

237423

PDB entries from 2025-06-11

PDB statisticsPDBj update infoContact PDBjnumon