4W9P
The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1S)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, E) | Peptidyl-prolyl cis-trans isomerase FKBP5 | polymer | 128 | 14026.1 | 2 | UniProt (Q13451) Pfam (PF00254) | Homo sapiens (Human) | PPIase FKBP5,51 kDa FK506-binding protein,FKBP-51,54 kDa progesterone receptor-associated immunophilin,Androgen-regulated protein 6,FF1 antigen,FK506-binding protein 5,FKBP-5,FKBP54,p54,HSP90-binding immunophilin,Rotamase |
| 2 | C, D (A, E) | (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1S)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one | non-polymer | 603.5 | 2 | Chemie (3JR) | |||
| 3 | E, F (E) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 4 | G, H (A, E) | water | water | 18.0 | 295 | Chemie (HOH) |
Sequence modifications
A, E: 16 - 140 (UniProt: Q13451)
| PDB | External Database | Details |
|---|---|---|
| Gly 13 | - | expression tag |
| Ala 14 | - | expression tag |
| Pro 15 | - | expression tag |
| Thr 19 | Ala 19 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28052.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1325.1 | |
| All* | Total formula weight | 29377.3 |
