4W9P

The Fk1 domain of FKBP51 in complex with (1S,5S,6R)-10-[(3,5-dichlorophenyl)sulfonyl]-5-[(1S)-1,2-dihydroxyethyl]-3-[2-(3,4-dimethoxyphenoxy)ethyl]-3,10-diazabicyclo[4.3.1]decan-2-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue 3JR A 201

Chain	Residue
A	TYR57
A	ALA112
A	TYR113
A	SER118
A	PHE130
A	HOH384
A	HOH418
A	HOH430
A	HOH434
E	3JR201
A	PHE67
A	ASP68
A	PHE77
A	GLY84
A	GLN85
A	VAL86
A	ILE87
A	TRP90

---

site_id	AC2
Number of Residues	19
Details	binding site for residue 3JR E 201

Chain	Residue
A	3JR201
E	TYR57
E	PHE67
E	ASP68
E	PHE77
E	GLY84
E	GLN85
E	VAL86
E	ILE87
E	TRP90
E	ALA112
E	TYR113
E	SER118
E	PHE130
E	HOH377
E	HOH388
E	HOH395
E	HOH428
E	HOH445

---

site_id	AC3
Number of Residues	8
Details	binding site for residue ACT E 202

Chain	Residue
A	HOH332
E	GLY13
E	ALA14
E	PRO15
E	MET48
E	ASP51
E	LYS60
E	GLY139

---

site_id	AC4
Number of Residues	7
Details	binding site for residue ACT E 203

Chain	Residue
A	HIS56
A	HOH330
A	HOH335
A	HOH339
E	SER62
E	ASN63
E	HOH441

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	176
Details	Domain: {"description":"PPIase FKBP-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"28147277","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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