4W2R
Structure of Hs/AcPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Enhancer of zeste 2 polycomb repressive complex 2 subunit | polymer | 643 | 72941.5 | 2 | UniProt (G1KPH4) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) | Anolis carolinensis (Green anole) | |
| 2 | C, D (E, F) | Polycomb protein EED | polymer | 362 | 41776.5 | 2 | UniProt (O75530) Pfam (PF00400) | Homo sapiens (Human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 3 | E, F (S, T) | Polycomb protein SUZ12 | polymer | 191 | 22268.7 | 2 | UniProt (Q15022) Pfam (PF09733) | Homo sapiens (Human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 4 | G, H, I, J, K... (A, B) | ZINC ION | non-polymer | 65.4 | 14 | Chemie (ZN) | |||
| 5 | N, V (A, B) | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | non-polymer | 467.3 | 2 | Chemie (CJD) |
Sequence modifications
A, B: 1 - 329 (UniProt: G1KPH4)
A, B: 330 - 388 (UniProt: G1KPH4)
A, B: 408 - 643 (UniProt: G1KPH4)
E, F: 67 - 427 (UniProt: O75530)
S, T: 545 - 725 (UniProt: Q15022)
A, B: 330 - 388 (UniProt: G1KPH4)
A, B: 408 - 643 (UniProt: G1KPH4)
| PDB | External Database | Details |
|---|---|---|
| Leu 389 | - | linker |
| Gly 390 | - | linker |
| Gly 391 | - | linker |
| Gly 392 | - | linker |
| Gly 393 | - | linker |
| Ser 394 | - | linker |
| Gly 395 | - | linker |
| Gly 396 | - | linker |
| Gly 397 | - | linker |
| Gly 398 | - | linker |
| Ser 399 | - | linker |
| Gly 400 | - | linker |
| Gly 401 | - | linker |
| Gly 402 | - | linker |
| Gly 403 | - | linker |
| Ser 404 | - | linker |
| Ala 405 | - | linker |
| Ala 406 | - | linker |
| Ala 407 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Met 66 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 535 | - | expression tag |
| Asp 536 | - | expression tag |
| Tyr 537 | - | expression tag |
| Lys 538 | - | expression tag |
| Asp 539 | - | expression tag |
| Asp 540 | - | expression tag |
| Asp 541 | - | expression tag |
| Asp 542 | - | expression tag |
| Lys 543 | - | expression tag |
| Gly 544 | - | expression tag |
| Asp 583 | Ser 583 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 273973.5 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1850.4 | |
| All* | Total formula weight | 275823.9 |
