4W2R
Structure of Hs/AcPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Enhancer of zeste 2 polycomb repressive complex 2 subunit | polymer | 643 | 72941.5 | 2 | UniProt (G1KPH4) Pfam (PF11616) Pfam (PF18118) Pfam (PF21358) Pfam (PF18264) Pfam (PF00856) In PDB | Anolis carolinensis (Green anole) | |
2 | E, F | Polycomb protein EED | polymer | 362 | 41776.5 | 2 | UniProt (O75530) Pfam (PF00400) In PDB | Homo sapiens (Human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
3 | S, T | Polycomb protein SUZ12 | polymer | 191 | 22268.7 | 2 | UniProt (Q15022) Pfam (PF09733) In PDB | Homo sapiens (Human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
4 | A, B | ZINC ION | non-polymer | 65.4 | 14 | Chemie (ZN) | |||
5 | A, B | 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one | non-polymer | 467.3 | 2 | Chemie (CJD) |
Sequence modifications
A, B: 1 - 329 (UniProt: G1KPH4)
A, B: 330 - 388 (UniProt: G1KPH4)
A, B: 408 - 643 (UniProt: G1KPH4)
E, F: 67 - 427 (UniProt: O75530)
S, T: 545 - 725 (UniProt: Q15022)
A, B: 330 - 388 (UniProt: G1KPH4)
A, B: 408 - 643 (UniProt: G1KPH4)
PDB | External Database | Details |
---|---|---|
Leu 389 | - | linker |
Gly 390 | - | linker |
Gly 391 | - | linker |
Gly 392 | - | linker |
Gly 393 | - | linker |
Ser 394 | - | linker |
Gly 395 | - | linker |
Gly 396 | - | linker |
Gly 397 | - | linker |
Gly 398 | - | linker |
Ser 399 | - | linker |
Gly 400 | - | linker |
Gly 401 | - | linker |
Gly 402 | - | linker |
Gly 403 | - | linker |
Ser 404 | - | linker |
Ala 405 | - | linker |
Ala 406 | - | linker |
Ala 407 | - | linker |
PDB | External Database | Details |
---|---|---|
Met 66 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 535 | - | expression tag |
Asp 536 | - | expression tag |
Tyr 537 | - | expression tag |
Lys 538 | - | expression tag |
Asp 539 | - | expression tag |
Asp 540 | - | expression tag |
Asp 541 | - | expression tag |
Asp 542 | - | expression tag |
Lys 543 | - | expression tag |
Gly 544 | - | expression tag |
Asp 583 | Ser 583 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 273973.5 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 1850.4 | |
All* | Total formula weight | 275823.9 |