Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

4W2R

Structure of Hs/AcPRC2 in complex with 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1(2H)-one

Functional Information from GO Data
ChainGOidnamespacecontents
A0006338biological_processchromatin remodeling
A0042054molecular_functionhistone methyltransferase activity
A0046976molecular_functionhistone H3K27 methyltransferase activity
B0006338biological_processchromatin remodeling
B0042054molecular_functionhistone methyltransferase activity
B0046976molecular_functionhistone H3K27 methyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 701
ChainResidue
ACYS420
AHIS422
ACYS427
ACYS431

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN A 702
ChainResidue
ACYS420
ACYS433
ACYS440
ACYS444

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN A 703
ChainResidue
ACYS440
ACYS446
ACYS450
ACYS427

site_idAC4
Number of Residues5
Detailsbinding site for residue ZN A 704
ChainResidue
ACYS457
ACYS459
ACYS463
ACYS468
AZN705

site_idAC5
Number of Residues5
Detailsbinding site for residue ZN A 705
ChainResidue
ACYS463
ACYS477
ACYS485
ACYS498
AZN704

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN A 706
ChainResidue
ACYS457
ACYS470
ACYS477
ACYS482

site_idAC7
Number of Residues4
Detailsbinding site for residue ZN A 707
ChainResidue
ACYS274
ACYS277
ACYS282
AHIS285

site_idAC8
Number of Residues11
Detailsbinding site for residue CJD A 708
ChainResidue
AILE109
ATYR111
AGLY520
ATRP521
ATYR555
ATYR558
ACYS560
APHE562
AARG582
APHE583
AASN585

site_idAC9
Number of Residues5
Detailsbinding site for residue ZN B 701
ChainResidue
BCYS427
BCYS440
BCYS446
BCYS450
BZN703

site_idAD1
Number of Residues5
Detailsbinding site for residue ZN B 702
ChainResidue
BCYS420
BCYS433
BCYS440
BCYS444
BZN703

site_idAD2
Number of Residues6
Detailsbinding site for residue ZN B 703
ChainResidue
BCYS420
BHIS422
BCYS427
BCYS431
BZN701
BZN702

site_idAD3
Number of Residues4
Detailsbinding site for residue ZN B 704
ChainResidue
BCYS457
BCYS470
BCYS477
BCYS482

site_idAD4
Number of Residues4
Detailsbinding site for residue ZN B 705
ChainResidue
BCYS463
BCYS477
BCYS485
BCYS498

site_idAD5
Number of Residues4
Detailsbinding site for residue ZN B 706
ChainResidue
BCYS457
BCYS459
BCYS463
BCYS468

site_idAD6
Number of Residues4
Detailsbinding site for residue ZN B 707
ChainResidue
BCYS274
BCYS277
BCYS282
BHIS285

site_idAD7
Number of Residues10
Detailsbinding site for residue CJD B 708
ChainResidue
BILE109
BTYR111
BTRP521
BTYR555
BTYR558
BPHE562
BARG582
BPHE583
BALA584
BASN585

Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI
ChainResidueDetails
ELEU192-ILE206

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI5
Number of Residues86
DetailsRepeat: {"description":"WD 1"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues86
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues80
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues82
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues74
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues80
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues308
DetailsRegion: {"description":"Required for interaction with the matrix protein MA of HIV-1"}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues6
DetailsModified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues152
DetailsRegion: {"description":"VEFS-box"}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18220336","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

PDB statisticsPDBj update infoContact PDBjnumon