4V9C

Allosteric control of the ribosome by small-molecule antibiotics

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, CB (AA, CA)	16S ribosomal RNA	polymer	1542	499690.0	2	GenBank (AP012306.1)	Escherichia coli
2	B, DB (AB, CB)	30S ribosomal protein S2	polymer	241	26781.7	2	UniProt (P0A7V0) Pfam (PF00318)	Escherichia coli
3	C, EB (AC, CC)	30S ribosomal protein S3	polymer	233	26031.3	2	UniProt (P0A7V3) Pfam (PF07650) Pfam (PF00189)	Escherichia coli
4	D, FB (AD, CD)	30S ribosomal protein S4	polymer	206	23514.2	2	UniProt (P0A7V8) Pfam (PF00163) Pfam (PF01479)	Escherichia coli
5	E, GB (AE, CE)	30S ribosomal protein S5	polymer	167	17629.4	2	UniProt (P0A7W1) Pfam (PF00333) Pfam (PF03719)	Escherichia coli
6	F, HB (AF, CF)	30S ribosomal protein S6	polymer	135	15727.5	2	UniProt (P02358) Pfam (PF01250)	Escherichia coli
7	G, IB (AG, CG)	30S ribosomal protein S7	polymer	179	20055.2	2	UniProt (P02359) Pfam (PF00177)	Escherichia coli
8	H, JB (AH, CH)	30S ribosomal protein S8	polymer	130	14146.6	2	UniProt (P0A7W7) Pfam (PF00410)	Escherichia coli
9	I, KB (AI, CI)	30S ribosomal protein S9	polymer	130	14886.3	2	UniProt (P0A7X3) Pfam (PF00380)	Escherichia coli
10	J, LB (AJ, CJ)	30S ribosomal protein S10	polymer	103	11755.6	2	UniProt (P0A7R5) Pfam (PF00338)	Escherichia coli
11	K, MB (AK, CK)	30S ribosomal protein S11	polymer	129	13871.0	2	UniProt (P0A7R9) Pfam (PF00411)	Escherichia coli
12	L, NB (AL, CL)	30S ribosomal protein S12	polymer	124	13768.2	2	UniProt (P0A7S3) Pfam (PF00164)	Escherichia coli
13	M, OB (AM, CM)	30S ribosomal protein S13	polymer	118	13128.5	2	UniProt (P0A7S9) Pfam (PF00416)	Escherichia coli
14	N, PB (AN, CN)	30S ribosomal protein S14	polymer	101	11606.6	2	UniProt (P0AG59) Pfam (PF00253)	Escherichia coli
15	O, QB (AO, CO)	30S ribosomal protein S15	polymer	89	10290.8	2	UniProt (P0ADZ4) Pfam (PF00312)	Escherichia coli
16	P, RB (AP, CP)	30S ribosomal protein S16	polymer	82	9207.6	2	UniProt (P0A7T3) Pfam (PF00886)	Escherichia coli
17	Q, SB (AQ, CQ)	30S ribosomal protein S17	polymer	84	9724.5	2	UniProt (P0AG63) Pfam (PF00366)	Escherichia coli
18	R, TB (AR, CR)	30S ribosomal protein S18	polymer	75	9005.5	2	UniProt (P0A7T7) Pfam (PF01084)	Escherichia coli
19	S, UB (AS, CS)	30S ribosomal protein S19	polymer	92	10455.4	2	UniProt (P0A7U3) Pfam (PF00203)	Escherichia coli
20	T, VB (AT, CT)	30S ribosomal protein S20	polymer	87	9708.5	2	UniProt (P0A7U7) Pfam (PF01649)	Escherichia coli
21	U, WB (AU, CU)	30S ribosomal protein S21	polymer	71	8524.0	2	UniProt (P68679) Pfam (PF01165)	Escherichia coli
22	V, XB (AV, CV)	Phenylalanine specific transfer RNA, tRNA-Phe	polymer	76	24485.5	2	GenBank (AP012306)	Escherichia coli
23	W, YB (AX, CX)	Messenger RNA, mRNA	polymer	24	7787.8	2
24	AC, X (BA, DA)	23S ribosomal RNA	polymer	2904	941612.4	2	GenBank (AP012306)	Escherichia coli
25	BC, Y (BB, DB)	5S ribosomal RNA	polymer	120	38790.1	2	GenBank (AP012306)	Escherichia coli
26	CC, Z (BC, DC)	50S ribosomal protein L2	polymer	273	29923.6	2	UniProt (P60422) Pfam (PF00181) Pfam (PF03947)	Escherichia coli
27	AA, DC (BD, DD)	50S ribosomal protein L3	polymer	209	22277.5	2	UniProt (P60438) Pfam (PF00297)	Escherichia coli
28	BA, EC (BE, DE)	50S ribosomal protein L4	polymer	201	22121.6	2	UniProt (P60723) Pfam (PF00573)	Escherichia coli
29	CA, FC (BF, DF)	50S ribosomal protein L5	polymer	179	20333.6	2	UniProt (P62399) Pfam (PF00281) Pfam (PF00673)	Escherichia coli
30	DA, GC (BG, DG)	50S ribosomal protein L6	polymer	177	18932.8	2	UniProt (P0AG55) Pfam (PF00347)	Escherichia coli
31	EA, HC (BH, DH)	50S ribosomal protein L9	polymer	149	15789.0	2	UniProt (P0A7R1) Pfam (PF01281) Pfam (PF03948)	Escherichia coli
32	FA, IC (BI, DI)	50S ribosomal protein L11	polymer	142	14894.4	2	UniProt (P0A7J7) Pfam (PF03946) Pfam (PF00298)	Escherichia coli
33	GA, JC (BJ, DJ)	50S ribosomal protein L13	polymer	142	16050.6	2	UniProt (P0AA10) Pfam (PF00572)	Escherichia coli
34	HA, KC (BK, DK)	50S ribosomal protein L14	polymer	123	13565.1	2	UniProt (P0ADY3) Pfam (PF00238)	Escherichia coli
35	IA, LC (BL, DL)	50S ribosomal protein L15	polymer	144	15008.5	2	UniProt (P02413) Pfam (PF00828)	Escherichia coli
36	JA, MC (BM, DM)	50S ribosomal protein L16	polymer	136	15312.3	2	UniProt (P0ADY7) Pfam (PF00252)	Escherichia coli
37	KA, NC (BN, DN)	50S ribosomal protein L17	polymer	127	14393.7	2	UniProt (P0AG44) Pfam (PF01196)	Escherichia coli
38	LA, OC (BO, DO)	50S ribosomal protein L18	polymer	117	12794.7	2	UniProt (P0C018) Pfam (PF00861)	Escherichia coli
39	MA, PC (BP, DP)	50S ribosomal protein L19	polymer	115	13159.3	2	UniProt (P0A7K6) Pfam (PF01245)	Escherichia coli
40	NA, QC (BQ, DQ)	50S ribosomal protein L20	polymer	118	13528.0	2	UniProt (P0A7L3) Pfam (PF00453)	Escherichia coli
41	OA, RC (BR, DR)	50S ribosomal protein L21	polymer	103	11586.4	2	UniProt (P0AG48) Pfam (PF00829)	Escherichia coli
42	PA, SC (BS, DS)	50S ribosomal protein L22	polymer	110	12253.4	2	UniProt (P61175) Pfam (PF00237)	Escherichia coli
43	QA, TC (BT, DT)	50S ribosomal protein L23	polymer	100	11222.2	2	UniProt (P0ADZ0) Pfam (PF00276)	Escherichia coli
44	RA, UC (BU, DU)	50S ribosomal protein L24	polymer	104	11339.3	2	UniProt (P60624) Pfam (PF00467) Pfam (PF17136)	Escherichia coli
45	SA, VC (BV, DV)	50S ribosomal protein L25	polymer	94	10713.5	2	UniProt (P68919) Pfam (PF01386)	Escherichia coli
46	TA, WC (BW, DW)	50S ribosomal protein L27	polymer	85	9146.5	2	UniProt (P0A7L8) Pfam (PF01016)	Escherichia coli
47	UA, XC (BX, DX)	50S ribosomal protein L28	polymer	78	9027.6	2	UniProt (P0A7M2) Pfam (PF00830)	Escherichia coli
48	VA, YC (BY, DY)	50S ribosomal protein L29	polymer	63	7286.5	2	UniProt (P0A7M6) Pfam (PF00831)	Escherichia coli
49	WA, ZC (BZ, DZ)	50S ribosomal protein L30	polymer	59	6554.8	2	UniProt (P0AG51) Pfam (PF00327)	Escherichia coli
50	AD, XA (B0, D0)	50S ribosomal protein L32	polymer	57	6463.4	2	UniProt (P0A7N4) Pfam (PF01783)	Escherichia coli
51	BD, YA (B1, D1)	50S ribosomal protein L33	polymer	55	6388.6	2	UniProt (P0A7N9) Pfam (PF00471)	Escherichia coli
52	CD, ZA (B2, D2)	50S ribosomal protein L34	polymer	46	5397.5	2	UniProt (P0A7P5) Pfam (PF00468)	Escherichia coli
53	AB, DD (B3, D3)	50S ribosomal protein L35	polymer	65	7313.0	2	UniProt (P0A7Q1) Pfam (PF01632)	Escherichia coli
54	BB, ED (B4, D4)	50S ribosomal protein L36	polymer	38	4377.4	2	UniProt (P0A7Q6) Pfam (PF00444)	Escherichia coli
55	ZB (CY)	Ribosome recycling factor, RRF	polymer	185	20671.6	1	UniProt (P0A805) Pfam (PF01765)	Escherichia coli
56	AE, AF, AG, AH, AI... (AA, BA, BB, CA, CX...)	MAGNESIUM ION	non-polymer		24.3	490	Chemie (MG)
57	CW, DW, EW, FW, GW... (DA, AA, BA, CA)	NEOMYCIN	non-polymer		614.6	18	Chemie (NMY)
58	FM, UW (B4, D4)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
59	AX, AY, BX, BY, CX... (AU, DN, BA, DQ, BB...)	water	water		18.0	1727	Chemie (HOH)

Sequence modifications

BB, DB: 1 - 120 (GenBank: AP012306)

PDB	External Database	Details
C 12	A 3600861	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	109
	Total formula weight	4379348.3
Non-Polymers*	Number of molecules	510
	Total formula weight	23103.9
All*	Total formula weight	4402452.1

*Water molecules are not included.