4V81

The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, I, Q, Y (A, I, a, i)	T-complex protein 1 subunit alpha	polymer	559	60557.6	4	UniProt (P12612) Pfam (PF00118)	Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast)	TCP-1-alpha, CCT-alpha
2	B, J, R, Z (B, J, b, j)	T-complex protein 1 subunit beta	polymer	527	57276.3	4	UniProt (P39076) Pfam (PF00118)	Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast)	TCP-1-beta, CCT-beta
3	AA, C, K, S (C, K, c, k)	T-complex protein 1 subunit gamma	polymer	590	64939.8	4	UniProt (P39077) Pfam (PF00118)	Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast)	TCP-1-gamma, CCT-gamma
4	BA, D, L, T (D, L, d, l)	T-complex protein 1 subunit delta	polymer	528	57740.4	4	UniProt (P39078) Pfam (PF00118)	Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast)	TCP-1-delta, CCT-delta
5	CA, E, M, U (E, M, e, m)	T-complex protein 1 subunit epsilon	polymer	562	61995.0	4	UniProt (P40413) Pfam (PF00118)	Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast)	TCP-1-epsilon, CCT-epsilon
6	DA, F, N, V (F, N, f, n)	T-complex protein 1 subunit zeta	polymer	546	59997.6	4	UniProt (P39079) Pfam (PF00118)	Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast)	TCP-1-zeta, CCT-zeta
7	EA, G, O, W (G, O, g, o)	T-complex protein 1 subunit eta	polymer	550	59802.4	4	UniProt (P42943) Pfam (PF00118)	Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast)	TCP-1-eta, CCT-eta
8	FA, H, P, X (H, P, h, p)	T-complex protein 1 subunit theta	polymer	568	61735.1	4	UniProt (P47079) Pfam (PF00118)	Saccharomyces cerevisiae (brewer's yeast lager beer yeast yeast)	TCP-1-theta, CCT-theta
9	AB, BC, CB, DC, EB... (L, l, M, m, N...)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	24	Chemie (ADP)
10	AC, BB, CC, DB, EC... (k, L, l, M, m...)	BERYLLIUM TRIFLUORIDE ION	non-polymer		66.0	24	Chemie (BEF)
11	GB, HC, NB, OB, WA... (O, o, c, d, I...)	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
12	KC, LC, MC, NC, OC... (B, E, G, M, e...)	water	water		18.0	7	Chemie (HOH)

Sequence modifications

C, K, c, k: 375 - 534 (UniProt: P39077)

PDB	External Database	Details
Gly 1001	-	SEE REMARK 999
Ser 1002	-	SEE REMARK 999
Gly 1003	-	SEE REMARK 999
Ser 1004	-	SEE REMARK 999
Gly 1005	-	SEE REMARK 999
Trp 1006	-	SEE REMARK 999
Ser 1007	-	SEE REMARK 999
His 1008	-	SEE REMARK 999
Pro 1009	-	SEE REMARK 999
Gln 1010	-	SEE REMARK 999
Phe 1011	-	SEE REMARK 999
Glu 1012	-	SEE REMARK 999
Lys 1013	-	SEE REMARK 999
Gly 1014	-	SEE REMARK 999
Ser 1015	-	SEE REMARK 999
Gly 1016	-	SEE REMARK 999
Lys 1017	-	SEE REMARK 999
Arg 1018	-	SEE REMARK 999
Arg 1019	-	SEE REMARK 999
Trp 1020	-	SEE REMARK 999
Lys 1021	-	SEE REMARK 999
Lys 1022	-	SEE REMARK 999
Asn 1023	-	SEE REMARK 999
Phe 1024	-	SEE REMARK 999
Ile 1025	-	SEE REMARK 999
Ala 1026	-	SEE REMARK 999
Val 1027	-	SEE REMARK 999
Ser 1028	-	SEE REMARK 999
Ala 1029	-	SEE REMARK 999
Ala 1030	-	SEE REMARK 999
Asn 1031	-	SEE REMARK 999
Arg 1032	-	SEE REMARK 999
Phe 1033	-	SEE REMARK 999
Lys 1034	-	SEE REMARK 999
Lys 1035	-	SEE REMARK 999
Ile 1036	-	SEE REMARK 999
Ser 1037	-	SEE REMARK 999
Ser 1038	-	SEE REMARK 999
Ser 1039	-	SEE REMARK 999
Gly 1040	-	SEE REMARK 999
Ala 1041	-	SEE REMARK 999
Leu 1042	-	SEE REMARK 999
Gly 1043	-	SEE REMARK 999
Ser 1044	-	SEE REMARK 999
Gly 1045	-	SEE REMARK 999
His 1046	-	SEE REMARK 999
His 1047	-	SEE REMARK 999
His 1048	-	SEE REMARK 999
His 1049	-	SEE REMARK 999
His 1050	-	SEE REMARK 999
His 1051	-	SEE REMARK 999
His 1052	-	SEE REMARK 999
His 1053	-	SEE REMARK 999
Gly 1054	-	SEE REMARK 999
Ser 1055	-	SEE REMARK 999
Gly 1056	-	SEE REMARK 999

D, L, d, l: 1 - 528 (UniProt: P39078)

PDB	External Database	Details
Asp 345	Gly 345	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	32
	Total formula weight	1936176.8
Non-Polymers*	Number of molecules	56
	Total formula weight	12605.5
All*	Total formula weight	1948782.3

*Water molecules are not included.