4V57

Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin and neomycin.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, AB (AA, CA)	16S rRNA	polymer	1542	499690.0	2	GenBank (836656) GenBank (85674274)	Escherichia coli
2	B, MB (AC, CC)	30S ribosomal protein S3	polymer	232	25900.1	2	UniProt (P0A7V3) Pfam (PF07650) Pfam (PF00189)	Escherichia coli
3	BB, C (AD, CD)	30S ribosomal protein S4	polymer	205	23383.0	2	UniProt (P0A7V8) Pfam (PF00163) Pfam (PF01479)	Escherichia coli
4	CB, D (AE, CE)	30S ribosomal protein S5	polymer	166	17498.2	2	UniProt (P0A7W1) Pfam (PF00333) Pfam (PF03719)	Escherichia coli
5	DB, E (AF, CF)	30S ribosomal protein S6	polymer	135	15727.5	2	UniProt (P02358) Pfam (PF01250)	Escherichia coli
6	F, NB (AG, CG)	30S ribosomal protein S7	polymer	178	19924.0	2	UniProt (P02359) Pfam (PF00177)	Escherichia coli
7	EB, G (AH, CH)	30S ribosomal protein S8	polymer	129	14015.4	2	UniProt (P0A7W7) Pfam (PF00410)	Escherichia coli
8	H, OB (AI, CI)	30S ribosomal protein S9	polymer	129	14755.1	2	UniProt (P0A7X3) Pfam (PF00380)	Escherichia coli
9	I, PB (AJ, CJ)	30S ribosomal protein S10	polymer	103	11755.6	2	UniProt (P0A7R5) Pfam (PF00338)	Escherichia coli
10	FB, J (AK, CK)	30S ribosomal protein S11	polymer	128	13739.8	2	UniProt (P0A7R9) Pfam (PF00411)	Escherichia coli
11	GB, K (AL, CL)	30S ribosomal protein S12	polymer	123	13637.0	2	UniProt (P0A7S3) Pfam (PF00164)	Escherichia coli
12	L, QB (AM, CM)	30S ribosomal protein S13	polymer	117	12997.3	2	UniProt (P0A7S9) Pfam (PF00416)	Escherichia coli
13	HB, M (AP, CP)	30S ribosomal protein S16	polymer	82	9207.6	2	UniProt (P0A7T3) Pfam (PF00886)	Escherichia coli
14	IB, N (AQ, CQ)	30S ribosomal protein S17	polymer	83	9593.3	2	UniProt (P0AG63) Pfam (PF00366)	Escherichia coli
15	JB, O (AR, CR)	30S ribosomal protein S18	polymer	74	8874.3	2	UniProt (P0A7T7) Pfam (PF01084)	Escherichia coli
16	P, SB (AS, CS)	30S ribosomal protein S19	polymer	91	10324.2	2	UniProt (P0A7U3) Pfam (PF00203)	Escherichia coli
17	KB, Q (AT, CT)	30S ribosomal protein S20	polymer	86	9577.3	2	UniProt (P0A7U7) Pfam (PF01649)	Escherichia coli
18	R, TB (AB, CB)	30S ribosomal protein S2	polymer	240	26650.5	2	UniProt (P0A7V0) Pfam (PF00318)	Escherichia coli
19	LB, S (AU, CU)	30S ribosomal protein S21	polymer	70	8392.8	2	UniProt (P68679) Pfam (PF01165)	Escherichia coli
20	T, UB (AO, CO)	30S ribosomal protein S15	polymer	89	10290.8	2	UniProt (P0ADZ4) Pfam (PF00312)	Escherichia coli
21	RB, U (AN, CN)	30S ribosomal protein S14	polymer	100	11475.4	2	UniProt (P0AG59) Pfam (PF00253)	Escherichia coli
22	V, VB (BA, DA)	5S rRNA	polymer	120	38790.1	2	GenBank (85674274)	Escherichia coli
23	W, WB (BB, DB)	23S rRNA	polymer	2904	941612.4	2	GenBank (85674274)	Escherichia coli
24	X, XB (BI, DI)	50S ribosomal protein L11	polymer	141	14763.2	2	UniProt (P0A7J7) Pfam (PF03946) Pfam (PF00298)	Escherichia coli
25	Y, YB (BC, DC)	50S ribosomal protein L2	polymer	272	29792.4	2	UniProt (P60422) Pfam (PF00181) Pfam (PF03947)	Escherichia coli
26	Z, ZB (BD, DD)	50S ribosomal protein L3	polymer	209	22277.5	2	UniProt (P60438) Pfam (PF00297)	Escherichia coli
27	AA, AC (BK, DK)	50S ribosomal protein L14	polymer	123	13565.1	2	UniProt (P0ADY3) Pfam (PF00238)	Escherichia coli
28	BA, BC (BP, DP)	50S ribosomal protein L19	polymer	114	13028.1	2	UniProt (P0A7K6) Pfam (PF01245)	Escherichia coli
29	CA, CC (BE, DE)	50S ribosomal protein L4	polymer	201	22121.6	2	UniProt (P60723) Pfam (PF00573)	Escherichia coli
30	DA, DC (BY, DY)	50S ribosomal protein L30	polymer	58	6423.6	2	UniProt (P0AG51) Pfam (PF00327)	Escherichia coli
31	EA, EC (B0, D0)	50S ribosomal protein L32	polymer	56	6332.2	2	UniProt (P0A7N4) Pfam (PF01783)	Escherichia coli
32	FA, FC (B4, D4)	50S ribosomal protein L36	polymer	38	4377.4	2	UniProt (P0A7Q6) Pfam (PF00444)	Escherichia coli	Ribosomal protein B
33	GA, GC (B1, D1)	50S ribosomal protein L33	polymer	54	6257.4	2	UniProt (P0A7N9) Pfam (PF00471)	Escherichia coli
34	HA, HC (B3, D3)	50S ribosomal protein L35	polymer	64	7181.8	2	UniProt (P0A7Q1) Pfam (PF01632)	Escherichia coli	Ribosomal protein A
35	IA, IC (BV, DV)	50S ribosomal protein L25	polymer	94	10713.5	2	UniProt (P68919) Pfam (PF01386)	Escherichia coli
36	JA, JC (B2, D2)	50S ribosomal protein L34	polymer	46	5397.5	2	UniProt (P0A7P5) Pfam (PF00468)	Escherichia coli
37	KA, KC (BL, DL)	50S ribosomal protein L15	polymer	144	15008.5	2	UniProt (P02413) Pfam (PF00828)	Escherichia coli
38	LA, LC (BM, DM)	50S ribosomal protein L16	polymer	136	15312.3	2	UniProt (P0ADY7) Pfam (PF00252)	Escherichia coli
39	MA, MC (BX, DX)	50S ribosomal protein L29	polymer	63	7286.5	2	UniProt (P0A7M6) Pfam (PF00831)	Escherichia coli
40	NA, NC (BH, DH)	50S ribosomal protein L9	polymer	149	15789.0	2	UniProt (P0A7R1) Pfam (PF01281) Pfam (PF03948)	Escherichia coli
41	OA, OC (BJ, DJ)	50S ribosomal protein L13	polymer	142	16050.6	2	UniProt (P0AA10) Pfam (PF00572)	Escherichia coli
42	PA, PC (BN, DN)	50S ribosomal protein L17	polymer	127	14393.7	2	UniProt (P0AG44) Pfam (PF01196)	Escherichia coli
43	QA, QC (BO, DO)	50S ribosomal protein L18	polymer	117	12794.7	2	UniProt (P0C018) Pfam (PF00861)	Escherichia coli
44	RA, RC (BQ, DQ)	50S ribosomal protein L20	polymer	117	13396.8	2	UniProt (P0A7L3) Pfam (PF00453)	Escherichia coli
45	SA, SC (BS, DS)	50S ribosomal protein L22	polymer	110	12253.4	2	UniProt (P61175) Pfam (PF00237)	Escherichia coli
46	TA, TC (BU, DU)	50S ribosomal protein L24	polymer	103	11208.1	2	UniProt (P60624) Pfam (PF00467) Pfam (PF17136)	Escherichia coli
47	UA, UC (BF, DF)	50S ribosomal protein L5	polymer	178	20202.4	2	UniProt (P62399) Pfam (PF00281) Pfam (PF00673)	Escherichia coli
48	VA, VC (BG, DG)	50S ribosomal protein L6	polymer	176	18801.6	2	UniProt (P0AG55) Pfam (PF00347)	Escherichia coli
49	WA, WC (BR, DR)	50S ribosomal protein L21	polymer	103	11586.4	2	UniProt (P0AG48) Pfam (PF00829)	Escherichia coli
50	XA, XC (BT, DT)	50S ribosomal protein L23	polymer	100	11222.2	2	UniProt (P0ADZ0) Pfam (PF00276)	Escherichia coli
51	YA, YC (BZ, DZ)	50S ribosomal protein L28	polymer	78	9027.6	2	UniProt (P0A7M2) Pfam (PF00830)	Escherichia coli
52	ZA, ZC (BW, DW)	50S ribosomal protein L27	polymer	84	9015.3	2	UniProt (P0A7L8) Pfam (PF01016)	Escherichia coli
53	AD, BM, KF, SJ (AA, DB, BB, CA)	NEOMYCIN	non-polymer		614.6	4	Chemie (NMY)
54	AE, AF, AG, AH, AI... (AA, BB, CA, DB)	MAGNESIUM ION	non-polymer		24.3	340	Chemie (MG)
55	AM, JF (CA, AA)	SPECTINOMYCIN	non-polymer		332.4	2	Chemie (SCM)
56	JQ, RJ (D4, B4)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
57	AR, BR, CR, DR, ER... (CP, CT, CI, CN, DB...)	water	water		18.0	1613	Chemie (HOH)

Sequence modifications

AA, CA: 1 - 1542 (GenBank: 836656)
BA, DA: 1 - 119 (GenBank: 85674274)

PDB	External Database	Details
U 120	-	insertion

BB, DB: 1 - 2902 (GenBank: 85674274)

PDB	External Database	Details
U 2903	-	insertion
U 2904	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	104
	Total formula weight	4286783.1
Non-Polymers*	Number of molecules	348
	Total formula weight	11517.8
All*	Total formula weight	4298300.9

*Water molecules are not included.