4V2V

JMJD2A COMPLEXED WITH NI(II), NOG AND HISTONE H3K27me3 PEPTIDE (25-29) ARK(me3)SA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	LYSINE-SPECIFIC DEMETHYLASE 4A	polymer	381	44326.3	2	UniProt (O75164) Pfam (PF02375) Pfam (PF02373)	HOMO SAPIENS (HUMAN)	1.14.11.-, JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN 3A, JUMONJI DOMAIN-CONTAINING PROTEIN 2A
2	C, D (C, D)	HISTONE H3.1T	polymer	5	575.7	2	UniProt (Q16695)	HOMO SAPIENS	H3/T, H3T, H3/G
3	E, I (A, B)	N-OXALYLGLYCINE	non-polymer		147.1	2	Chemie (OGA)
4	F, J (A, B)	NICKEL (II) ION	non-polymer		58.7	2	Chemie (NI)
5	G, K (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	H (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
7	L, M, N, O (A, B, C, D)	water	water		18.0	469	Chemie (HOH)

Sequence modifications

A, B: 1 - 359 (UniProt: O75164)

PDB	External Database	Details
Met -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Val -11	-	expression tag
Asp -10	-	expression tag
Leu -9	-	expression tag
Gly -8	-	expression tag
Thr -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	89803.9
Non-Polymers*	Number of molecules	7
	Total formula weight	577.8
All*	Total formula weight	90381.8

*Water molecules are not included.