4V1M
Architecture of the RNA polymerase II-Mediator core transcription initiation complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 | polymer | 1733 | 191821.6 | 1 | UniProt (P04050) Pfam (PF04997) Pfam (PF05001) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) Pfam (PF04992) Pfam (PF04990) In PDB | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | RNA POLYMERASE II SUBUNIT 1, RNA POLYMERASE II SUBUNIT B1, DNA-DIRECTED RNA POLYMERASE III LARGEST SUBUNIT, RNA POLYMERASE II SUBUNIT B220 |
| 2 | B | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 | polymer | 1224 | 138937.3 | 1 | UniProt (P08518) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) In PDB | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | RNA POLYMERASE II SUBUNIT 2, B150, DNA-DIRECTED RNA POLYMERASE II 140 KDA POLYPEPTIDE |
| 3 | C | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3 | polymer | 318 | 35330.5 | 1 | UniProt (P16370) Pfam (PF01193) Pfam (PF01000) In PDB | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | RNA POLYMERASE II SUBUNIT 3, RNA POLYMERASE II SUBUNIT B3, B44.5, DNA-DIRECTED RNA POLYMERASE II 45 KDA POLYPEPTIDE |
| 4 | E | DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 | polymer | 215 | 25117.1 | 1 | UniProt (P20434) Pfam (PF03871) Pfam (PF01191) In PDB | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | RNA POLYMERASES I\,II\,AND III SUBUNIT ABC1, ABC27, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III 27 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III SUBUNIT RPABC 1 |
| 5 | F | DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 2 | polymer | 155 | 17931.8 | 1 | UniProt (P20435) Pfam (PF01192) In PDB | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | RNA POLYMERASES I\,II\,AND III SUBUNIT ABC2, ABC23, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III 23 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III SUBUNIT RPABC 2 |
| 6 | H | DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 3 | polymer | 146 | 16525.4 | 1 | UniProt (P20436) Pfam (PF03870) In PDB | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | RNA POLYMERASES I, II, AND III SUBUNIT ABC3, ABC14.4, ABC14.5, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III 14.5 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III SUBUNIT RPABC 3 |
| 7 | I | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9 | polymer | 122 | 14308.2 | 1 | UniProt (P27999) Pfam (PF02150) Pfam (PF01096) In PDB | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | RNA POLYMERASE II SUBUNIT B9, B12.6, DNA-DIRECTED POLYMERASE II 14.2 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II SUBUNIT 9 |
| 8 | J | DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 5 | polymer | 70 | 8290.7 | 1 | UniProt (P22139) Pfam (PF01194) In PDB | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | RNA POLYMERASES I\,II\,AND III SUBUNIT ABC5, ABC10-BETA, ABC8, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III 8.3 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III SUBUNIT RPABC 5 |
| 9 | K | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11 | polymer | 120 | 13633.5 | 1 | UniProt (P38902) Pfam (PF13656) Pfam (PF01193) In PDB | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | RNA POLYMERASE II SUBUNIT B11, B13.6, DNA-DIRECTED RNA POLYMERASE II 13.6 KDA POLYPEPTIDE |
| 10 | L | DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 4 | polymer | 70 | 7730.0 | 1 | UniProt (P40422) Pfam (PF03604) In PDB | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | RNA POLYMERASES I\,II\,AND III SUBUNIT ABC4, ABC10-ALPHA, DNA-DIRECTED RNA POLYMERASES I\,II\,AND III SUBUNIT RPABC 4 |
| 11 | N | 5'-D(*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP)-3' | polymer | 10 | 3068.0 | 1 | SYNTHETIC CONSTRUCT | NONTEMPLATE DNA | |
| 12 | P | 5'-D(*CP*CP*AP*GP*GP*AP)-3' | polymer | 6 | 1914.2 | 1 | SYNTHETIC CONSTRUCT | ||
| 13 | T | 5'-D(*TP*CP*AP*AP*GP*TP*AP*CP*TP*TP*TP*TP*TP*CP *CP*BRUP*GP*GP*TP*C)-3' | polymer | 20 | 6130.8 | 1 | SYNTHETIC CONSTRUCT | TEMPLATE DNA | |
| 14 | A, B, C, I, J... | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 15 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 13 |
| Total formula weight | 480739.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 547.6 | |
| All* | Total formula weight | 481286.6 |
