4V0C

Crystal Structure of the Kv7.1 proximal C-terminal Domain in Complex with Calmodulin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1	polymer	112	13488.3	2	UniProt (P51787) In PDB	HOMO SAPIENS (HUMAN)	IKS PRODUCING SLOW VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT ALPHA KVLQT1, KQT-LIKE 1, VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.1, KV7.1 CHANNEL
2	C, D	CALMODULIN	polymer	149	16852.5	2	UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23) In PDB	HOMO SAPIENS (HUMAN)	CAM, KV7.1 CHANNEL
3	A	THIOCYANATE ION	non-polymer		58.1	1	Chemie (SCN)
4	C, D	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
5		water	water		18.0	4	Chemie (HOH)

Sequence modifications

A, B: 352 - 396 (UniProt: P51787)

PDB	External Database	Details
Met 324	-	expression tag
Gly 325	-	expression tag
Ser 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
His 333	-	expression tag
His 334	-	expression tag
Gly 335	-	expression tag
Ser 336	-	expression tag
Asp 337	-	expression tag
Tyr 338	-	expression tag
Asp 339	-	expression tag
Asp 340	-	expression tag
Ile 341	-	expression tag
Phe 342	-	expression tag
Thr 343	-	expression tag
Thr 344	-	expression tag
Glu 345	-	expression tag
Asn 346	-	expression tag
Leu 347	-	expression tag
Tyr 348	-	expression tag
Phe 349	-	expression tag
Gln 350	-	expression tag
Gly 350	-	expression tag
Ser 351	-	expression tag

A, B: 397 - 539 (UniProt: P51787)

PDB	External Database	Details
Glu 397	His 502	engineered mutation
Phe 398	Ile 503	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	60681.6
Non-Polymers*	Number of molecules	5
	Total formula weight	218.4
All*	Total formula weight	60900.0

*Water molecules are not included.