4UZB

KSHV LANA (ORF73) C-terminal domain mutant bound to LBS1 DNA (R1039Q, R1040Q, K1055E, K1109A, D1110A, A1121E, K1138S, K1140D, K1141D)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	ORF 73	polymer	141	15896.1	2	UniProt (Q76SB0) Pfam (PF21501) UniProt (by SIFTS) (Q9QR71) In PDB	HUMAN HERPESVIRUS 8	LATENCY-ASSOCIATED NUCLEAR ANTIGEN, LANA-1, KSHV LANA
2	C	LANA BINDING SITE 1 DNA	polymer	20	6137.9	1	GenBank (1841835)	HUMAN HERPESVIRUS 8
3	D	LANA BINDING SITE 1 DNA	polymer	20	6137.9	1	GenBank (1841835)	HUMAN HERPESVIRUS 8
4		water	water		18.0	105	Chemie (HOH)

Sequence modifications

A, B: 1008 - 1146 (UniProt: Q76SB0)

PDB	External Database	Details
Gly 1006	-	expression tag
Ser 1007	-	expression tag
Gln 1039	Arg 1039	engineered mutation
Gln 1040	Arg 1040	engineered mutation
Glu 1055	Lys 1055	engineered mutation
Ala 1109	Lys 1109	engineered mutation
Ala 1110	Asp 1110	engineered mutation
Glu 1121	Ala 1121	engineered mutation
Ser 1138	Lys 1138	engineered mutation
Asp 1140	Lys 1140	engineered mutation
Asp 1141	Lys 1141	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	44068.0
All*	Total formula weight	44068.0

*Water molecules are not included.