4UYH

N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-((2R,4S)-2-methyl-4-(phenylamino)-6-(4-(piperidin-1-ylmethyl)phenyl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	BROMODOMAIN-CONTAINING PROTEIN 2	polymer	154	17908.7	3	UniProt (P25440) Pfam (PF00439)	HOMO SAPIENS (HUMAN)	O27.1.1, REALLY INTERESTING NEW GENE 3 PROTEIN, HUMAN BRD2
2	D, E (A, B)	1-[(2S,4R)-2-methyl-4-(phenylamino)-6-[4-(piperidin-1-ylmethyl)phenyl]-3,4-dihydroquinolin-1(2H)-yl]ethanone	non-polymer		453.6	2	Chemie (9S3)
3	F (B)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	G (C)	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
5	H, I, J (A, B, C)	water	water		18.0	396	Chemie (HOH)

Sequence modifications

A, B, C: 67 - 200 (UniProt: P25440)

PDB	External Database	Details
Gly 47	-	expression tag
Ser 48	-	expression tag
Ser 49	-	expression tag
His 50	-	expression tag
His 51	-	expression tag
His 52	-	expression tag
His 53	-	expression tag
His 54	-	expression tag
His 55	-	expression tag
Ser 56	-	expression tag
Ser 57	-	expression tag
Gly 58	-	expression tag
Leu 59	-	expression tag
Val 60	-	expression tag
Pro 61	-	expression tag
Arg 62	-	expression tag
Gly 63	-	expression tag
Ser 64	-	expression tag
His 65	-	expression tag
Met 66	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	53726.2
Non-Polymers*	Number of molecules	4
	Total formula weight	1081.4
All*	Total formula weight	54807.6

*Water molecules are not included.