4UYH
N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1-((2R,4S)-2-methyl-4-(phenylamino)-6-(4-(piperidin-1-ylmethyl)phenyl)-3,4-dihydroquinolin-1(2H)-yl)ethanone
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DMS C 1182 |
| Chain | Residue |
| C | VAL103 |
| C | ASN156 |
| C | ILE162 |
| C | HOH2038 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE 9S3 A 1184 |
| Chain | Residue |
| A | ASN156 |
| A | ILE162 |
| A | HOH2071 |
| B | GLN94 |
| A | TRP97 |
| A | PRO98 |
| A | LYS107 |
| A | LEU108 |
| A | LEU110 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 9S3 B 1183 |
| Chain | Residue |
| A | GLN94 |
| B | PRO98 |
| B | LYS107 |
| B | LEU108 |
| B | LEU110 |
| B | ASN156 |
| B | ILE162 |
| B | HOH2050 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1184 |
| Chain | Residue |
| B | ARG100 |
| B | HOH2016 |
| B | HOH2018 |
| B | HOH2126 |
| C | ARG128 |
| C | ASN132 |
| C | TYR134 |
| C | HOH2057 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
