4UYF
N-Terminal bromodomain of Human BRD2 with I-BET726 (GSK1324726A)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BROMODOMAIN-CONTAINING PROTEIN 2 | polymer | 154 | 17893.7 | 1 | UniProt (P25440) Pfam (PF00439) | HOMO SAPIENS (HUMAN) | O27.1.1, REALLY INTERESTING NEW GENE 3 PROTEIN, HUMAN BRD2 |
| 2 | B, C (B, C) | BROMODOMAIN-CONTAINING PROTEIN 2 | polymer | 154 | 17908.7 | 2 | UniProt (P25440) Pfam (PF00439) | HOMO SAPIENS (HUMAN) | O27.1.1, REALLY INTERESTING NEW GENE 3 PROTEIN, HUMAN BRD2 |
| 3 | D, G, J (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | E, H, K (A, B, C) | 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl]benzoic acid | non-polymer | 434.9 | 3 | Chemie (73B) | |||
| 5 | F, I, L (A, B, C) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 6 | M, N, O (A, B, C) | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence modifications
A: 67 - 200 (UniProt: P25440)
B, C: 67 - 200 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Gly 47 | - | expression tag |
| Ser 48 | - | expression tag |
| Ser 49 | - | expression tag |
| His 50 | - | expression tag |
| His 51 | - | expression tag |
| His 52 | - | expression tag |
| His 53 | - | expression tag |
| His 54 | - | expression tag |
| His 55 | - | expression tag |
| Ser 56 | - | expression tag |
| Ser 57 | - | expression tag |
| Gly 58 | - | expression tag |
| Leu 59 | - | expression tag |
| Val 60 | - | expression tag |
| Pro 61 | - | expression tag |
| Arg 62 | - | expression tag |
| Gly 63 | - | expression tag |
| Ser 64 | - | expression tag |
| His 65 | - | expression tag |
| Met 66 | - | expression tag |
| Asn 71 | Lys 71 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 47 | - | expression tag |
| Ser 48 | - | expression tag |
| Ser 49 | - | expression tag |
| His 50 | - | expression tag |
| His 51 | - | expression tag |
| His 52 | - | expression tag |
| His 53 | - | expression tag |
| His 54 | - | expression tag |
| His 55 | - | expression tag |
| Ser 56 | - | expression tag |
| Ser 57 | - | expression tag |
| Gly 58 | - | expression tag |
| Leu 59 | - | expression tag |
| Val 60 | - | expression tag |
| Pro 61 | - | expression tag |
| Arg 62 | - | expression tag |
| Gly 63 | - | expression tag |
| Ser 64 | - | expression tag |
| His 65 | - | expression tag |
| Met 66 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 53711.1 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1779.1 | |
| All* | Total formula weight | 55490.2 |
